Colistin sulfate is an antibiotic polypeptide which possesses activity mainly against Gram negative bacteria, and in veterinary medicine is used orally for the treatment or prevention of enteritis in production animals.

Function 

Colistin sulfate is highly effective against strains of Escherichia coli,Pseudomonas aeruginosa, Salmonella spp., Haemophilus spp.,Shigella spp., Pasteurella spp., Brucella spp., Aerobacter aerogenes and Bordetella bronchiseptica. Gram positive bacteria are generally less sensitive, but there are some sensitive strains such asStaphylococcus spp., Bacillus spp., Streptococcus pyogenes andCorynebacterium spp.

Application 

1. A growth promoter used in Peru in poultry and pork production is sulfate colistin, an antibiotic belonging to the polymyxin group. 
2. Salmonellosis is an important disease in poultry and pork production, because of the implications that arise in Public Health, the restrictions on the marketing of products from infected farms and the impact on health programs of farms. The most common clinical manifestation of this disease is enteritis, which is often presented as a bloody or profuse watery diarrhea accompanied by fever, but you can see a broad spectrum of clinical symptoms, such as acute septicemia,abortion, arthritis, necrosis on extremities and respiratory disease.