China 99% High Purity Veterinary Drugs CAS 1264-72-8 Colistin Sulfate, Find details about China Colistin Sulfate 99%, Colistin Sulfate from 99% High Purity Veterinary Drugs CAS 1264-72-8 Colistin Sulfate
Colistin sulfate
CAS No.:1264-72-8
MF:2(C52H98N16O13).5(H2SO4)
EINECS No.:215-034-3
Purity: 99%
Standard:EP5
Appearance : white crystal powder
Description:
Colistin sulfate, a cationic polypeptide from the polymyxin family, has been shown to be an extremely potent antibiotic that iseffective against most gram-negative Bacilli. Mechanistic studies have reported that this compound induces apoptosis throughinteraction with the cytoplasmic membrane. Additional studies have demonstrated that Colistin sulphate is extremely toxic. Toxic effects noted include neurotoxicity, nephrotoxicity, vascular congestion of brain vessels, and extreme kidney and CNS negative effects.
Function:
Used for prevention and treatment of various intestinal disease caused by pathogenic microorganism ( E.coli, salmonella, etc.) and the pool feeding and management. such as poor appetite, drawing a yellow, green , thin , feed stool ,etc. Bleeding, swelling or fall off of intestinal mucosaafter dissection.
Characteristic:
1) Improve growth performance and conversion rate of livestock & poultry;
2) Inhibit Gram-negative bacteria at growth duration or dormancy state;
3) Prevent bacterial diarrhea & synergistic effects with other antibiotics;
4) No cross tolerance with broad range of antibacterial agent;
5) Little absorbed by intestine and stomach, no residue.
Specification:
Test | Specification |
Characteristics | White or almost white powder |
Identification | Meets EP specification |
PH | 4.0 ~ 6.0 |
Loss on drying | ≤3.5% |
Optical rotation | -63° ~ -73° |
Sulphated ash | ≤1.0% |
Sulphate (dried basis) | 16.0% ~ 18.0% |
Content (Dry basis HPLC)
| Colistin E1-I≤10% |
Colistin E1-7MOA≤10% | |
Colistin E3≤10% | |
E1+ E2+E3+E1-I+E1-7MOA≥77.0% | |
Related substances | Any impurity≤4.0% |
| Total impurity≤23.0% |
Potency(Moisture basis) | ------- |
Potency (Dried basis) | ≥19000IU/mg |