Clean in Place system is a critical equipment in bio-pharmaceutical in order to obtain GMP certification. It has become necessary supplementary equipment for the biological system due to its simple operation method and reliable washing quality. CIP system also can reduce working intensity as it can wash the bioreactors and pipelines without disassembling it. The cleaning effect can be quantifiable via conductivity measurement & automated program for feedback control. This can standardize the cleaning procedure more effectively & efficiently.


 


 
(a) The MCIP Clean system consists of:

1. Floor-type structure with mobile wheels and tray.
2. 2 units of stainless steel 316L CIP tanks each for alkali, and hot water respectively.
3. 1 unit of sanitary centrifugal pump is provided for circulating and mixing the alkali and acid solutions, and supply CIP solution to subjected tank.
4. 1 unit of heat exchanger for heating up CIP solution
5. 2 units of PE tanks and reciprocating pumps for dosing of hot water/ alkali stock solutions into the CIP tank
6. 1 unit of sanitary centrifugal pumps for CIP return/ drain
7. 1 unit of pressure gauge at CIP supply line to indicate the pressure in the line

(b) Control System: 

1. The system is based on SIEMENS PLC
2. Control cabinet is provided for the system, and the cabinet is mounted on the same skid with CIP tank
3. It is able to monitor and record critical CIP parameters: CIP supply temperature, CIP supply pressure, CIP supply & drain conductivity.  

(c) Piping:

1. All piping is self-draining
2. All pipe is made of SS 316L
3. The piping is fitted with manual valves, flow switches, supply pump, drain pump, and pressure gauge
4. Internal surface of piping is Ra<0.8u and external surface is Ra<1.2u

(d) Normal Procedure of Operation:

1. Washing with Hot Water: 35-60^oC, 10-15minutes
2. Water flushing: 30-40^oC, 10-15minutes
3. Washing with Alkali: 60-70^oC, 15-20minutes
4. Washing with purified water: 40-50^oC, 15-20minutes

(e) The CIP procedure can be set on HMI touch screen of PLC control system, and can be operated automatically or semi-automatically.