Selective Androgen Inhibitors Mk- 1775 Oral Steroids CAS 955365-80-7 for Bodyhealth with Safety Delivery

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Model NO.
QIGE
Storage
Keep in a Cool and Dry Place
Molecular Formula
C27h32n8o2
MW
500.59538
Trademark
qige
Transport Package
Drum
Specification
99%
Origin
China
Model NO.
QIGE
Storage
Keep in a Cool and Dry Place
Molecular Formula
C27h32n8o2
MW
500.59538
Trademark
qige
Transport Package
Drum
Specification
99%
Origin
China
 Gurantee 100% safe shipping, free of EU customs clearance. We will ship by special line that shipping company do custom clearance and deliver to door. 100% safe deliver
 

Selective Androgen Inhibitors MK-1775 Oral Steroids CAS 955365-80-7 for Bodyhealth
Basic Info.

Product Name: MK-1775
Product Name: 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
Synonyms: 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one;MK-1775;MK-1775,MK1775;2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one;2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK 1775;MK 1775 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one;MK-1775, >=98%;MK-1175
CAS: 955365-80-7
MF: C27H32N8O2
MW: 500.59538 

Description:

MK-1775 information:

MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared to Wee1, MK-1775 displays 2- to 3-fold less potency against Yes with IC50 of 14 nM, 10-fold less potency against seven other kinases with >80% inhibition at 1 μM, and >100-fold selectivity over human Myt 1, another kinase that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at an alternative site (Thr14). By abrogating the DNA damage checkpoint via blockade of Wee1 activity in WiDr cells bearing mutated p53, MK-1775 treatment inhibits the basal phosphorylation of CDC2 at Tyr15 (CDC2Y15) with EC50 of 49 nM, and suppresses gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of CDC2 and cell cycle arrest in a dose-dependent manner, with EC50 of 82 nM and 81 nM, 180 nM and 163 nM, as well as 159 nM and 160 nM, respectively. MK-1775 treatment alone at 30-100 nM has no significant antiproliferative effect in WiDr and H1299 cells, whereas MK-1775 at 300 nM, sufficient to inhibit Wee1 by >80%, displays moderate but significant antiproliferative effects by 34.1% in WiDr cells and 28.4% in H1299 cells.
in vivo: MK-1775 treatment alone at ~20 mg/kg displays minimal antitumor effects against WiDr xenografts in rats with T/C of 69% at day 3. Antitumor efficacy by MK-1775 alone in the nude rat HeLa-luc and TOV21G-shp53 xenograft models models is also moderate



Raw Pharmaceutical Active Ingredients Estriol CAS 50-27-1 Female Hormones

Related Products:
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
3. How to cooperate with us?
You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.






 


Packaging Details

1.25kg packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside.Or according customer requairments.

2.Delivery Time:whith 3-5 working days after get the payment.

3.Shipping:We have professional shipping afent,based on customers'requairments for transport.

4.By express: Fedex, DHL, EMS,UPS etc.   By sea and By air

Drug Eutylone /EU CAS 802855-66-9

Drug Eutylone /EU CAS 802855-66-9

Payment terms: TT,Bitcoin,Western union , Money gram or Bank transfer
Delivery: 1-3 working days after payment confirmed
Shipping: Door to door safe deliver by air,by sea,express including EMS,DHL,UPS,TNT,FedEX
Packaging Details: Safe package or as required
Discount: Large quantity ordered
 

Package and shipping:

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Packaging Details:25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside

Delivery Detail: within 3 days when get the payment.

Shipping :

We have Professional shipping agent, based on customers ' demand for transport
By express :FEDEX,DHL,EMS ,UPS,TNT ect.
By SEA and By AIR
Procaine CAS 59-46-1
Selective Androgen Inhibitors Mk-1775 Oral Steroids CAS 955365-80-7 for Bodyhealth with Safety Delivery