Product Description:

MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared to Wee1, MK-1775 displays 2- to 3-fold less potency against Yes with IC50 of 14 nM, 10-fold less potency against seven other kinases with >80% inhibition at 1 μM, and >100-fold selectivity over human Myt 1, another kinase that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at an alternative site (Thr14). By abrogating the DNA damage checkpoint via blockade of Wee1 activity in WiDr cells bearing mutated p53, MK-1775 treatment inhibits the basal phosphorylation of CDC2 at Tyr15 (CDC2Y15) with EC50 of 49 nM, and suppresses gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of CDC2 and cell cycle arrest in a dose-dependent manner, with EC50 of 82 nM and 81 nM, 180 nM and 163 nM, as well as 159 nM and 160 nM, respectively. MK-1775 treatment alone at 30-100 nM has no significant antiproliferative effect in WiDr and H1299 cells, whereas MK-1775 at 300 nM, sufficient to inhibit Wee1 by >80%, displays moderate but significant antiproliferative effects by 34.1% in WiDr cells and 28.4% in H1299 cells.
in vivo: MK-1775 treatment alone at ~20 mg/kg displays minimal antitumor effects against WiDr xenografts in rats with T/C of 69% at day 3. Antitumor efficacy by MK-1775 alone in the nude rat HeLa-luc and TOV21G-shp53 xenograft models models is also moderate.

Our Company

Guangzhou Biocar Pharmacy Co., Ltd., formerly known as Guangdong Yangye Pharmaceutical Factory established in 2005, is affiliated to Wuhan Biocar Group. With the rise of Internet +, company's business process is accelerating. The company's board of directors has decided to establish Guangzhou Yangye Biotechnology Co., Ltd. At the end of 2016. We have established close and stable cooperative relationship with over 420 manufacturers with long-term with consistent suppliers at India and China. Now the company has formed into a comprehensive chemical enterprise integrating scientific research, development, production, sales and service under all staffs' endless efforts.

Guangzhou Biocar Pharmacy Co., Ltd. is located near Zhujiang New Town, Tianhe District, one of the prosperous areas in Guangzhou. This helps facilitate business negotiations at home and abroad. It is a high-tech enterprise centered in Guangdong, radiating across our country and facing the world. And it is mainly engaged in the research, development and sales of new chemical raw materials, the custom synthesis and import and export of pharmaceutical intermediates and APIs, the agency sales of pharmaceutical chemicals, the research and development, production and sales of flavors, fragrances and chemical raw materials. Its factory covers an area of more than 4, 000 acres and has more than 600 employees. It has always adhered to the tenet of "Being faithful, cultivating harmony and achieving win-win cooperation" and treats every customer sincerely.

We are looking forward to cooperating with you sincerely, and making mutual benefit and brilliance!

Our Service 

 1.Cooperate with research institutions, we strictly control the process from raw material to finished product.

 2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.

 3.We can send the goods to your delivery address directly. It is relatively safe and fast. 

 4.Quick and clear response to customers questions.

 5.We could make our price discount if you place a substantial order with us.

 6.Products can be packaged according to customer requirements.


FAQ

Q1: Have your Product Quality been Approved by the Third Party Lab?
A: Yes, all the products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 

Q2. Is there any discount?
A: Of course, for the larger quantity, we always support with better price for our further cooperation. 

Q3. What is your package?
A: Powder: PE bag, glass bottle or PTFE bottle for inner packing, and then into the aluminium foil bag for outer packing.
Liquid: glass bottle or PTFE bottle for inner packing, and then into the aluminium foil bag for outer packing.
Bulk order: Fiber drum or steel drum.

Q4. Will you provide the sample for testing the quality?
A: We'd like to offer free samples to our clients for the quality evaluation for most products, but the shipping cost is borne by clients.

Q5. What are the payment terms?
A: We can accept the T/T, Western Union, Money Gram, PayPal, Bitcoin etc.

Q6: How long does it take the goods to arrive?
A: It is Depending on your location,
For the small order, please expect the 5-7 days by DHL,UPS,TNT, FEDEX, EMS and so on.
For the mass order, please allow the 5-8 days by Air or 20-35 days by Sea.

Q7: How do you treat quality complaint?
A: First of all, our QC department will do the strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem, caused by us, we will send you free goods for replacement or refund your loss.