Main effects and indications of Fructus aurantii: stagnation, fullness, swelling and pain, secret stool, heavy diarrhea, chest knot, gastroptosis, uterine prolapse and anal prolapse. Fructus aurantii has bitter taste and cold nature. It is easy to hurt the spleen and stomach, so the weak spleen and stomach and pregnant women should take it carefully. Long service of Fructus aurantii is easy to damage the spleen and stomach. There are also reports of Qi loss caused by taking Fructus aurantii for too long. Fructus aurantii also has good curative effect on cardiovascular and cerebrovascular system. Fructus aurantii extract, Fructus aurantii injection and their effective components can strengthen the heart, increase cardiac output, shrink blood vessels, increase total peripheral resistance, and increase left ventricular pressure and arterial blood pressure. The effects of Fructus aurantii and Fructus aurantii Decoction on isolated toad heart were enhanced at low concentration; The contraction decreased at high concentration. N-methyltyramine can also enhance the contractility of isolated and in vivo hearts. Fructus aurantii, Fructus aurantii Decoction and Fructus aurantii ethanol extract were injected intravenously into anesthetized rabbits and dogs. P-hydroxyfulin and n-methyltyramine are two effective components isolated from Fructus aurantii injection. 
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