Product Name: Nicotinamide Mononucleotide
Appearance: White powder
Specification: 98%
CAS NO:1094-61-7

Description:
Nicotinamide mononucleotides play an important role in the production of human cell energy, which is involved in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion).
Nicotinamide Mononucleotide belongs to Vitamin B, participating in metabolism in the body, can be used to prevent pellagra or other niacin defection disease.
Nicotinamide Mononucleotide could be used as feed/human nutrition, booth the growth and strengthen the immunity. Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide.Niacinamide (nicotinamide) is a derivative of vitamin B3, also known as niacin. As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.Its precursor, niacin, is found in a variety of nutritional sources: peanuts, mushrooms (portobello, grilled), avocados, green peas (fresh), and certain fish and animal meats.In studies on mice, NMN has shown to reverse age-related arterial dysfunction by decreasing oxidative stress. A long-term study indicates that NMN can slow down the physiologic decline in ageing mice. As a result, the older mice in the study have metabolism and energy levels resembling those of younger mice, with extended life spans. However, NMN did not show similar beneficial effects in young mice. The anti-ageing properties are being tested on humans in Japan.

The Metabolism of Nucleotides

Before we look at nucleic acid structure, we need to study the synthesis of the purine and pyrimidine ribonucleotides and the subsequent synthesis of the deoxyribonucleotides, followed by their catabolic and recycling pathways. The synthetic pathways are particularly detailed, and I suggest that you review my introduction to the study of biochemical pathways so that you can break the information down into manageable pieces. Along the way, we will correlate the information, where appropriate, to disease states. In such instances, I will use the header "Clinical Correlate".

Purine Ribonucleotide Synthesis

Surprisingly, the purine ribonucleotides are formed as such de novo, and the bases themselves are derived from them. The first purine ribonucleotide to be synthesized in an organism is inosine monophosphate.

5'-Nucleotides are produced through the hydrolytic reaction from Ribonucleic acid(RNA) as raw material by enzymatic catalysis to form four kinds of nucleotides 5- 'AMP (adenosine-5'-monophosphate), 5'-GMP•2Na(guanosine-5'-monophosphate, disodium salt), 5'-CMP(cytidine-5'-monophosphate)-, 5'-UMP•2Na (uridine- 5'-monophosphate,Disodium salt) .By the chromatographic isolation, four kinds of separated 5'-nucleotide products with high purity can be obtained. These products can be widely applied in medicine, reagent, fine chemical industry, and additive of food fields etc.

β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a c oenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleot ide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins.

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Company Profile
Hefei JOYE Import & Export CO.,LTD is a import and export trade company established in 2011.Approved by the Chinese government set up trade enterprises.The Customs Registration code of the company is 3401961603.

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