China API-Vancomycin HCl, High Purity CAS 1404-93-9 Vancomycin Hydrochloride, Find details about China Pharmaceutical Intermediates, Chemical from API-Vancomycin HCl, High Purity CAS 1404-93-9 Vancomycin Hydrochloride
Description:
Vancomycin hydrochloride is a glycopeptide antibiotic and is the hydrochloride salt of vancomycin. It is white or white-like crystalline powder at room temperature. Its mechanism of action is that it can bind with high affinity to the poly-terminus alanyl-alanine of the precursor peptide located on the cell wall the sensitive bacterial cells, blocking the biosynthesis of the peptide glycan polymer constituting the bacterial cell wall, and thus resulting in the defects of cell wall and further killing bacteria. In addition, it is also possible to change the permeability of the bacterial cell membrane, and selectively inhibit the synthesis of RNA.
The characteristic of vancomycin hydrochloride is its strong bactericidal effect against Gram-positive bacteria such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and streptococcus pneumoniae. It also has certain anti-bacteria effects on Streptococci anaerobius, Clostridium difficile, Bacillus anthracis, Actinomycetes, Corynebacterium diphtheria, Neisseria gonorrhoeae, Streptococcus viridans,Streptococcus bovis, and Streptococcus faecalis.
However, for most Gram-negative bacteria, Mycobacterium,Rickettsia genus,Chlamydia or fungi, it is invalid. It is clinically applicable to the treatment of infection caused by methicillin-resistant Staphylococcus aureus and other bacteria:sepsis, endocarditis,osteomyelitis, arthritis, burns injury, surgical trauma and other superficial secondary infection, pneumonia, lung abscess, empyema, peritonitis,meningitis, pseudomembranous colitis, and skin and soft tissue infections. It is the primary choice for patients who are allergic to penicillin and suffer from the enterococcal endocarditis and Corynebacterium (class diphtheria sp)endocarditis.
Application:
Vancomycin is an antibiotic used to treat a number of bacterial infections.It is recommended intravenously as a first-line treatment for complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant S. aureus.Blood levels may be measured to determine the correct dose.Vancomycin is also recommended by mouth as a treatment for severe Clostridium difficile colitis. When taken by mouth it is very poorly absorbed.
Vancomycin is indicated for the treatment of serious, life-threatening infections by gram-positive bacteria unresponsive to other antibiotics. In particular, vancomycin should not be used to treat methicillin-sensitive Staphylococcus aureus because it is inferior to penicillins such as nafcillin.
Specification:
Item | Requirements | Test Results |
Appearance | A white or almost white powder | A white or almost white powder |
Identification | The retention time of the principal peak in the chromatogram obtained with test solution(a) is similar to the reference solution , comples Reaction (a) of chlorides ,complies | Complies |
Appearance of solution | Clear | Clear |
Water | ≤5.0% | 1.9% |
Ph | 2.5~4.5 | 2.9 |
Limit of monodechlorovancomycin | ≤4.7% | Complies |
Sulphated ash | ≤1.0% | Complies |
Assay(microbial)(anhydrous basis) | ≥900 μg/mg | ≥900 μg/mg |
Bacterial endotoxins | ≤ 0.33EU/mg | Complies |
Sterility | Sterility | Sterility |
Heavy metals | ≤30ppm | <30ppm |
Composition of Cancomycin | Vancomycin B:≥ 85.0% Any peak other than the main peak:≤5.0% | 94.3% 1.5% |
Conclusion | Complies with USP 36 |
Usage:
Vancomycin hydrochloride is the salt of a glycopeptide antibiotic isolated from Amycolatopsis orientalis in 1956. Vancomycin exhibits potent activity against Gram positive bacteria and is highly effective against MRSA in vitro and in vivo. Vancomycin interferes with cell wall synthesis by binding to D-alanine-D-alanine residues.
Packing:
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