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Introduction
Product Name | Carbamazepine |
MF | C15H12N2O |
EINECS | 206-062-7 |
Related categories | API; Protein and derivatives; Medical raw materials; Compounds; Medicine anti-depression; Pharmaceutical raw materials-scientific research raw materials; Medical raw materials; Raw materials; Medical raw materials; Raw materials; Standard products; Scientific research raw materials of pharmaceutical raw materials; Drug impurities and intermediates; Other APIs; Antidepressant; HeterocyclicCompounds; |
Melting point | 189-192 °C |
The mechanism of action of carbamazepine and its derivatives is relatively well understood.[medical citation needed] Carbamazepine is a use-dependant blocker of voltage-gated sodium channels. It is ionised within intracellular fluid, and is then able to bind to activated voltage-gated sodium channels, preventing repetitive and sustained firing of an action potential.This leaves the affected cells less excitable until the drug dissociates. Carbamazepine is also a GABA receptor agonist, as it has also been shown to potentiate GABA receptors made up of alpha1, beta2, and gamma2 subunits.[26] This mechanism may contribute to its efficacy in neuropathic pain and bipolar disorder. Laboratory research has further demonstrated that carbamazepine is a serotonin releasing agent and possibly even a serotonin reuptake inhibitor.
SpecificationItem | Specifications |
Appearance | White or off-white crystalline powder |
Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL |
Purity(by HPLC) | ≥99.0% |
Melting point | 189-192 °C |
Storage | 2-8°C |
Loss on drying | ≤0.50% |