Most mouthpieces take some time to adapt to. However, some devices I tried were downright painful and took several nights to get used to wearing. Snore RX, on the other hand, was relatively comfortable, and it's designed to allow full mouth-breathing. This can be especially helpful for people who naturally breathe through their mouths or suffer from sinus problems that prevent nasal breathing.
The Snore RX mouthpiece includes cushioning on the teeth for added comfort, and I really appreciated the Posi-Lock feature that prevents setting changes while you sleep. This product is certified by the American Academy of Sleep Medicine, the gold standard by which sleep medical services are evaluated.