Factory Supply DMF for Widely Application

Product Instruction

Product Name: DMF

Molecular Weight: 73.09

Molecular Formula: C3H7NO

EINECS: 200-679-5

Melting point: -61 °C

Alpha: 0.94 º

Boiling point: 153 °C(lit.)

Density: 0.948 g/mL at 20 °C

Storage temp: Store at RT.

Solubility: water: miscible

Form: powder

Color: white

PH: 7 (200g/l, H2O, 20ºC)

InChIKey: ZMXDDKWLCZADIW-UHFFFAOYSA-N

Product Instruction:

Description

DMFlfor is an organic compound with the formula (CH3)2NC(O)H. Commonly abbreviated as DMF (although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority of organic liquids. DMF is a common solvent for chemical reactions. Dimethylfor is odorless, but technical-grade or degraded samples often have a fishy smell due to impurity of dimethylamine. Dimethylamine degradation impurities can be removed by sparging degraded samples with an inert gas such as argon or by sonicating the samples under reduced pressure. As its name indicates, it is a derivative of formamide, the amide of formic acid. DMF is a polar (hydrophilic) aprotic solventwith a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2reactions.

Structure and properties

As for most amides, the spectroscopic evidence indicates partial double bond character for the C-N and C-O bonds. Thus, the infrared spectrum shows a C=O stretching frequency at only 1675 cm−1, whereas a ketone would absorb near 1700 cm−1. The ambient temperature 1H NMR spectrum shows separate methyl signals, indicative of hindered rotation about the (O)C-N bond.

 DMF is miscible with water.  The vapour pressure at 20 °C is 3.5 hPa.  A Henry's law constant of 7.47 × 10−5 hPa m3 mol−1 can be deduced from an experimentally determined equilibrium constant at 25 °C.[8] The partition coefficient log POW is measured to −0.85.  Since the density of DMF (0.95 g cm⁻³ at 20 °C) is similar to that of water, significant flotation or stratification in surface waters in case of accidental losses is not expected.

Applications

The primary use of DMF is as a solvent with low evaporation rate.  DMF is used in the production of acrylic fibers and plastics. It is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production of pesticides, and in the manufacture of adhesives, synthetic leathers, fibers, films, and surface coatings.

It is used as a reagent in the Bouveault aldehyde synthesis  and in the Vilsmeier-Haack reaction,  another useful method of forming aldehydes.

It is a common solvent in the Heck reaction.
It is also a common catalyst used in the synthesis of acyl halides, in particular the synthesis of acyl chlorides from carboxylic acids using oxalyl or thionyl chloride. The catalytic mechanism entails reversible formation of an imidoyl chloride.

DMF penetrates most plastics and makes them swell. Because of this property DMF is suitable for solid phase peptide synthesis and as a component of paint strippers.

DMF is used as a solvent to recover olefins such as 1,3-butadiene via extractive distillation.
It is also used in the manufacturing of solvent dyes as an important raw material. It is consumed during reaction.

Pure acetylene gas cannot be compressed and stored without the danger of explosion. Industrial acetylene is safely compressed in the presence of dimethylformamide, which forms a safe, concentrated solution. The casing is also filled with agamassan, which renders it safe to transport and use.