Factory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril

China Factory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril, Find details about China Lisinopril CAS 83915-83-7, Lisinopril Powder from Factory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril

Model NO.
Lisinopril
CAS Number
CAS83915-83-7
Appearance
a Slightly Brown of off White Powder
Water
8.0~9.5%
Loss on Drying
≤5.0%
Assay
98.6%
Trademark
Arshine
Transport Package
Bag, Drum
Specification
25kg/drum
Origin
China
Model NO.
Lisinopril
CAS Number
CAS83915-83-7
Appearance
a Slightly Brown of off White Powder
Water
8.0~9.5%
Loss on Drying
≤5.0%
Assay
98.6%
Trademark
Arshine
Transport Package
Bag, Drum
Specification
25kg/drum
Origin
China
Factory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril 
Factory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril

Lisinopril is a third-generation angiotensin-converting enzyme inhibitor and a lysine derivative of enalapril. It was marketed in the United States in 1987 for the treatment of hypertension and is a first-line antihypertensive drug . The pharmacological action characteristics are similar to Enalapril (Enalapril), with strong angiotensin-converting enzyme inhibitory effect, quick onset and long action time, just take the medicine once a day. The inhibitory effect on ACE is 6 to 8 times that of captopril and 1 to 3 times that of benazepril.
Function and Application 

Angiotensin Converting Enzyme Inhibitor (ACE-I), a lysine derivative of Enalapril, is the third non-sulfhydryl group in the world to be marketed. ACE-I. Long-acting, once a day, and the dosage is only 1/20 of captopril, 1/4 of enalapril, oral bioavailability is better. The curative effect is remarkable. For moderate and severe patients, the Chemicalbook should be better than captopril and enalapril. It has no direct effect on the heart, does not cause arrhythmia, has no central effect, and has no adverse reactions such as blood pressure rebound. It can be used for diseases accompanied by diabetes, asthma, peripheral vascular disease, psychosis and congestive heart failure, and for other diseases Patients with hypertension who are contraindicated in the treatment of drugs. It is effective for short-term and long-term congestive heart failure.

Product NameLisinopril dlhydrate
ReferenceUSP
TestSpecificationResults
CharactersWhite crystalline powder.White crystalline powder.
Identification1) Infrared absorption spectrum concordant with spectrum obtained with Lisinopril dihydrate RS.Conform
2) The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that of the Standard preparation obtained as directed in the Assay.Conform
Specific optical rotation [a]Hg25-115.3-122.5°-119.6°
Water8.0~9.5%8.3%
Residue on ignition≤0.1%<0.1%
Assay (HPLC)98.0-102.0% (calculated on anhydrous basis)98.6%
Residual solventsEthanol≤0.5%0.017%
Related substances (HPLC)DL-Homophenylalanine ≤0.30%<RL(RL:0.05%)
Related compound A ≤0.3%<RL(RL:0.05%)
R,S,S-Diketopiperazine ≤0.3%<LOD(LOD:0.01%)
Lisinopril epimer ≤0.3%0.07%
Lisinopril cyclohexyl analogue ≤0.30%0.08%
N-Alkyl-L-lysine ≤0.3%0.09%
N-Alkyl lisinopril ≤0.15%<LOD(LOD:0.01%)
Any individual unspecified impurity≤0.10%<RL(RL:0.05%)
Total imp. does not include lisinopril epimer≤0.5%0.17%
ConclusionComplies with USP

 

Factory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril
Factory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril
Factory Supply High Quality Raw Material CAS 83915-83-7 LisinoprilFactory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril
Factory Supply High Quality Raw Material CAS 83915-83-7 LisinoprilFactory Supply High Quality Raw Material CAS 83915-83-7 LisinoprilFactory Supply High Quality Raw Material CAS 83915-83-7 LisinoprilFactory Supply High Quality Raw Material CAS 83915-83-7 LisinoprilFactory Supply High Quality Raw Material CAS 83915-83-7 LisinoprilFactory Supply High Quality Raw Material CAS 83915-83-7 Lisinopril