Genipin is an aglycone derived from an iridoid glycoside called Geniposide present in fruit of Gardenia jasmindides Ellis. Genipin is an excellent natural cross-linker for protein, collagen, gelatin, and chitosan cross-linking. It has much less toxic than glutaraldehyde and many other commonly used synthetic cross -linking regents. It is also used for pharmaceutical purposes, such as choleretic action for liver diseases control.