China Propitocaine Hydrochloride 1786-81-8 Prilocaine HCl/Proparacaine HCl 5875-06-9/Alogliptin Benzoate 850649-62-6/Dasatinib 302962-49-8/486460-32-6 Sitagliptin, Find details about China Sitagliptin, 486460-32-6 from Propitocaine Hydrochloride 1786-81-8 Prilocaine HCl/Proparacaine HCl 5875-06-9/Alogliptin Benzoate 850649-62-6/Dasatinib 302962-49-8/486460-32-6 Sitagliptin
Introduction
product Name | Sitagliptin |
---|---|
Molecular Formula | C16H15F6N5O |
Molecular Weight | 407.3136 |
InChI | InChI=1/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m0/s1 |
CAS Registry Number | 486460-32-6;790712-60-6 |
Molecular Structure | |
Density | 1.614g/cm3 |
Boiling point | 529.905°C at 760 mmHg |
Refractive index | 1.59 |
Flash point | 274.277°C |
Vapour Pressur | 0mmHg at 25°C |
Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.
Application
An anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.
Sitagliptin phosphate monohydrate should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis, as it would not be effective in these settings.
Sitagliptin phosphate monohydratehas not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk for the development of pancreatitis while using Sitagliptin phosphate monohydrate.
Specification
Appearance | White or almost White powder | White powder |
Solubility | Easy to dissolve in the water | Complies |
Identification | High -performance liquid chromatograph HPLC | Almost the same |
Infrared absorption | Almost the same | |
Melting point | 203.0-205.0ºC | 204.0~205.0ºC |
Chiral impurity: | ≤1.0% | 0.4%
|
Related Impurities: | Total Impurities ≤1.0% | 0.63% |
Water | ≤1.0% | 0.6% |
Heavy metals | ≤20ppm | <20ppm |
Residue on ignition | ≤0.1% | 0.01 % |
Specific Rotation | Between -18.0 °and 23.0° | -21.05° |
HPLC Assay | 98.0% ~ 102.0% | 99.5% |