Product Information

Applications

Background

Angiotensinogen is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. It is a member of the serpin family. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that raises blood pressure. Angiotensin also stimulates the release of aldosterone, another hormone, from the adrenal cortex. Aldosterone promotes sodium retention in the distal nephron, in the kidney, which also drives blood pressure up.      

Images

Western blot analysis of Angiotensinogen (GB11394) at dilution of 1:600. Lane 1: Mouse liver tissue lysate Lane 2: Mouse kidney tissue lysate Lane 3: Mouse brain tissue lysate Lane 4: Rat liver tissue lysate Lane 5: Rat kidney tissue lysate Lane 6: Rat brain tissue lysate

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Shipped at 4ºC. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.