China Anti -Kmt1b / SUV39h2 Rabbit Primary Polyclonal Antibody, Find details about China for Research Only, Liquid from Anti -Kmt1b / SUV39h2 Rabbit Primary Polyclonal Antibody
Anti -KMT1B / SUV39H2 Rabbit Primary Polyclonal Antibody
Product Information
Description | SUV39H2 rabbit polyclonal |
Protein full name | Histone-lysine N-methyltransferase SUV39H2 |
Synonyms | Histone H3-K9 methyltransferase 2, KMT1B, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2, Su(var)3-9 homolog 2, SUV39H2 |
Immunogen | Recombinant protein corresponding to Mouse SUV39H2 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Nucleus |
Uniprot ID | Q9H5I1 |
Applications
Applications | IHC | IF |
Species | Human | Human |
Dilution | 1: 1000-1: 2000 | 1: 500-1: 1000 |
Positive tissue | breast cancer | breast cancer |
Background
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
Images
Immunohistochemistry analysis of paraffin-embedded human breast cancer using SUV39H2 (GB111054) at dilution of 1: 2000 |
Storage | Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium-azide, 100 μg/ml BSA and 50% glycerol. |