Cheap Poly-L-Glutamic Acid CAS 84960-48-5//Poly (L-glutamate) CAS 25513 -46-6//Succimer CAS 304-55-2/Dmsa//CAS 2418-14-6 Dimercaptosuccinic Acid
China Cheap Poly-L-Glutamic Acid CAS 84960-48-5//Poly (L-glutamate) CAS 25513-46-6//Succimer CAS 304-55-2/Dmsa//CAS 2418-14-6 Dimercaptosuccinic Acid, Find details about China CAS 2418-14-6, Dmsa from Cheap Poly-L-Glutamic Acid CAS 84960-48-5//Poly (L-glutamate) CAS 25513-46-6//Succimer CAS 304-55-2/Dmsa//CAS 2418-14-6 Dimercaptosuccinic Acid
Basic Info.
Model NO.
Dimercaptosuccinic acid
Mf
C4h6o4s2
MW
182.22
CAS
2418-14-6
Appearance
White Powder
Function
Biological and Pharmaceutical Intermediates
Shelf Life
2 Years
Test Method
HPLC UV
Storage
Cool Dry Place
Payment
Tt.Western Union .Credit Card.Moneygram
Delivery Time
Within 2 Days
Certificate
COA MSDS
Sample
Available
Trademark
Faithful
Transport Package
Aluminum Foil Bag Packaging
Specification
10g/bag; 100g/bag; 1kg/bag; 25KG/BAG
Origin
China
Model NO.
Dimercaptosuccinic acid
Mf
C4h6o4s2
MW
182.22
CAS
2418-14-6
Appearance
White Powder
Function
Biological and Pharmaceutical Intermediates
Shelf Life
2 Years
Test Method
HPLC UV
Storage
Cool Dry Place
Payment
Tt.Western Union .Credit Card.Moneygram
Delivery Time
Within 2 Days
Certificate
COA MSDS
Sample
Available
Trademark
Faithful
Transport Package
Aluminum Foil Bag Packaging
Specification
10g/bag; 100g/bag; 1kg/bag; 25KG/BAG
Origin
China
Product Desciption
Cheap Poly-l-glutamic Acid CAS 84960-48-5//Poly(L-glutamate) CAS 25513-46-6//Succimer CAS 304-55-2/DMSA//CAS 2418-14-6 Dimercaptosuccinic acidIntroduction
| Product Name | Dimercaptosuccinic acid |
| CAS NO | 2418-14-6 |
| Molecular Weight | 182.218 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 267.6±40.0 °C at 760 mmHg |
| Molecular Formula | C4H6O4S2 |
| Melting Point | 196-198ºC |
| Flash Point | 115.6±27.3 °C |
Function
DMSA Powder is the organosulfur compound with the formula HO2CCH(SH)CH(SH)CO2H. This colorless solid contains two carboxylic acid and two thiol groups, the latter being responsible for its mildly unpleasant odour. It occurs in two diastereomers, meso and the chiral dl forms. The meso isomer is used as achelating agent. The acid is most often used as a treatment for heavy metal toxicity, and is a water soluble and non-toxic substance.
DMSA Powder is indicated for the treatment of lead poisoning in children with blood level measured above 45 µg/dL. The use of DMSA is not approved for prophylactic/prevention of lead poisoning in anticipation of exposure in known lead contaminated environments. Its elimination half-life is 2.5-3.5 h. DMSA can cross the blood-brain barrier of mice, but not that of humans, limiting its use to extracting heavy metals from parts of the body other than the central nervous system.
Another application for DMSA is for provocation of tissue heavy metals in anticipation of a urine test. This is sometimes called a "challenge" or "provoked" heavy metals test. DMSA is used to help mobilize heavy metals stored in body tissues (and therefore not typically present in the circulation) and increase the excretion of heavy metals in the urine. In a study by Howard Frumkin et al., this sort of test was shown to not reliably provide an indication of past chronic mercu exposure, something it was often used for. A 2004 study by GP Archbold, et al. called the results of a DMSA challenge test "misleading" for the purposes of diagnosing mercutoxicity. Moreover, DMSA share the limitation of extracellular distribution, which makes it unable to cross the cell membrane and chelate heavy metals from intracellular sites.
The relative activities of a series of novel monoalkyl esters of meso-2,3-dimercaptosuccinic acid (DMSA) have been examined as agents for the mobilization of cadmium, lead and arsenic owing to the ability of these monoesters to cross cell membranes. The monoesters were found to be more effective than the parent compound DMSA.
DMSA Powder is indicated for the treatment of lead poisoning in children with blood level measured above 45 µg/dL. The use of DMSA is not approved for prophylactic/prevention of lead poisoning in anticipation of exposure in known lead contaminated environments. Its elimination half-life is 2.5-3.5 h. DMSA can cross the blood-brain barrier of mice, but not that of humans, limiting its use to extracting heavy metals from parts of the body other than the central nervous system.
Another application for DMSA is for provocation of tissue heavy metals in anticipation of a urine test. This is sometimes called a "challenge" or "provoked" heavy metals test. DMSA is used to help mobilize heavy metals stored in body tissues (and therefore not typically present in the circulation) and increase the excretion of heavy metals in the urine. In a study by Howard Frumkin et al., this sort of test was shown to not reliably provide an indication of past chronic mercu exposure, something it was often used for. A 2004 study by GP Archbold, et al. called the results of a DMSA challenge test "misleading" for the purposes of diagnosing mercutoxicity. Moreover, DMSA share the limitation of extracellular distribution, which makes it unable to cross the cell membrane and chelate heavy metals from intracellular sites.
The relative activities of a series of novel monoalkyl esters of meso-2,3-dimercaptosuccinic acid (DMSA) have been examined as agents for the mobilization of cadmium, lead and arsenic owing to the ability of these monoesters to cross cell membranes. The monoesters were found to be more effective than the parent compound DMSA.
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