Introduction

 Tiamulin is a semi-synthetic derivative of Pleuromutilin. It is highly active against gram-positive organisms such as streptococci, staphylococci and against mycoplasmas and serpulina (Treponema) hyodysenteriae. A number of Shigella, Klebsiella and E. coli are also quite susceptible to this agent. Some anaerobic species including Bacteroides fragilis and Clostridium perfringens with no exception are sensitive to tiamulin.
Tiamulin acts bacteriostatically. The biochemical basis for the antibacterial action is inhibition of protein synthesis, by binding to 70S ribosomes.
Tiamulin is used for prevention and control of mycoplasmal diseases such as enzootic pneumonia and chronic respiratory disease in pigs and poultry; and swine dysentery, porcine colonic spirochaetosis and porcine proliferative enteropathy.

Function

 It is mainly used to prevent and cure chicken chronic respiratory disease, Mycoplasma pneumoniae (asthma), actinomycosis and Treponema. Low dose can promote growth and improve feed utilization.