Clemastine fumarate
Chemical Name: 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1methylpyrrolidine
CAS NO.: 14976-57-9
EINECS: 239-055-2
Molecular Formula: C21H26ClNO. C4H4O4
Molecular Weight: 459.97
Characteristics: White or most white crystalline powder, odorless, a little bitter taste.
Solubility: Light soluble in methanol, minimal soluble in water or chloromethane.
Mp: 177~178° C
Assay: ≥ 99.0%(HPLC)
Standard: USP/BP/CP/EP
Usage: Raw meterial, Clemastine fumarate is a new generation H1 receptor antagonist, it is used to reduce adverse reactions of antihistamines such as the existence of sedation.
Package: 1kg/tin, 0.5kg/tin.
Storage Situation: Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Shelf Life: Two years when properly stored.
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| Analysis item | Standard | Analysis results |
| Appearance | White or off-white crystalline powder | White crystalline powder |
| Clarity and Color of solution | 1,Clear and not more opalescent than the reference solution
2,Colorless or not more intensely colored than color of matching fluid | Conform
|
| Specific Rotation | +15°~+18° | +17.01° |
| pH | 3.2~4.2 | 3.61 |
| Loss on drying | less than0.5% | 0.12% |
| Heavy metals | less than 0.002% | Conform |
Related Materials
Chromatographic purity | 1,Individual Max impurity, no more than 0.5%
2,Total impurities , no more than 1.0% | 1,0.20%
2,0.35% |
| Assay | 98.0~102.0% | 99.4% |