China Hot!!!56786-63-1 5A-Hydroxy Laxogenin//28319-77-9 Alpha GPC/Choline Glycerophosphate//Galantamine Hydrobromide/Galantamine Hbr 1953-04-4//357-70-0 Galantamine, Find details about China Galantamine, 357-70-0 from Hot!!!56786-63-1 5A-Hydroxy Laxogenin//28319-77-9 Alpha GPC/Choline Glycerophosphate//Galantamine Hydrobromide/Galantamine Hbr 1953-04-4//357-70-0 Galantamine
Introduction
Function
Galantamine is used for the treatment of mild to moderate Alzheimer's disease and various other
memory impairments, particularly those of vascular origin. It is an alkaloid that is obtained synthetically or from the bulbs and flowers of Galanthus Caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) and related genera like Narcissus (daffodil)), Leucojum(snowflake) and Lycoris including Lycoris radiata .
Application
Galanthamine is natural extracted from lycoris radiate,is a tertiary alkaloid derived from snow drop and closely related species.It acts as a reversible competitive acetylcholinesterase (ACHE) inhibitor, while acts weaker on butyrylcholinesterse(BuChE).it is used in the treatment of disorders of the central nerbous system and may be used as an antidote to nonpolarizing muscle relaxants.Galanthamine hydrobromide is a white to almost white powder; sparingly soluble in water; insoluble chlorofor, ether and alcohol .
Specification
ITEMS | SPECIFICATION | RESULTS |
Appearance | crystalline powder | Conforms |
Melting point | About 205°C | 206.4°C~206.7°C |
Identification | Meet the requirements | Conforms |
Appearance of solution | Clear, not more intense than Y7 | Conforms |
PH | 2.4~3.0 | 2.60 |
Loss on drying | ≤0.5% | 0.04% |
Sulphated ash | ≤0.1% | 0.01% |
Heavy metals | ≤20 ppm | <20 ppm |
Related substances | ≤0.25% | Conforms |
Assay | 99.0%~101.0% | 99.8% |
Identification | Meet the requirements | Conforms |
Loss on drying | ≤0.5% | 0.04% |
Residue on ignition | ≤0.1% | 0.01% |
Heavy metals | ≤0.003% | <0.003% |
Residue solvent - Ethanol | ≤0.5% | <0.04% |
Chloride | 16.9%~17.6% | 17.1% |
Assay | 98.0%~102.0% | 100.0% |