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Model NO.
Estriol
Mf
C18h24o3
MW
288.38
CAS
50-27-1
Appearance
White Crystalline Powder
Function
Biological and Pharmaceutical Intermediates
Shelf Life
2 Years
Test Method
HPLC UV
Storage
Cool Dry Place
Payment
Tt.Western Union .Credit Card.Moneygram
Delivery Time
Within 2 Days
Certificate
COA MSDS
Sample
Available
Trademark
Faithful
Transport Package
Aluminum Foil Bag Packaging
Specification
10g/bag; 100g/bag; 1kg/bag
Origin
China
Model NO.
Estriol
Mf
C18h24o3
MW
288.38
CAS
50-27-1
Appearance
White Crystalline Powder
Function
Biological and Pharmaceutical Intermediates
Shelf Life
2 Years
Test Method
HPLC UV
Storage
Cool Dry Place
Payment
Tt.Western Union .Credit Card.Moneygram
Delivery Time
Within 2 Days
Certificate
COA MSDS
Sample
Available
Trademark
Faithful
Transport Package
Aluminum Foil Bag Packaging
Specification
10g/bag; 100g/bag; 1kg/bag
Origin
China
High Quality Low Price Dl-Dithiothreitol 3483-12-3//Octenidine Dihydrochloride 70775-75-6//Calcifediol 19356-17-3//Isatoic Anhydride 118-48-9//50-27-1 EstriolHigh quality low price DL-Dithiothreitol 3483-12-3//Octenidine dihydrochloride 70775-75-6//Calcifediol 19356-17-3//isatoic anhydride 118-48-9//50-27-1 Estriol

Introduction

Product nameEstriol
CAS no.50-27-1
Molecular FormulaC18H24O3
Molecular Weight288.38

Function

Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estrone. Levels of estriol in women who are not pregnant are almost undetectable. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.
Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDAor Health Canada.
Functional primary care: 1. Used for uterine cervix, especially for postmenopausal syndromes and senile vaginitis. Can be used as an adjuvant for intermediate and induced abortion. Used for enlarged prostate, prostate cancer, etc. The function of leukocyte is rapidly elevated, which takes effect from 1 to 3 days after taking the drug, but the effect is shorter. Loss of white blood cells due to chemotherapy or radiation therapy. 5. Can reduce the permeability of blood vessels and brittle, and can be used for a variety of the treatment of bleeding, menorrhagia, tonsil or after hysterectomy, have rapid hemostatic effect
.

Application

Estriol is a G protein-coupled estrogen receptor antagonist, which can act on estrogen receptor-negative breast cancer cells.

Specification
 

ITEMSPECIFICATIONRESULT
CharacterWhite or almost white crystalline powderWhite crystalline powder
Specific rotation+54°to +62°+59.9°
Completeness of solutionClear and free from undissolved solidConforms
Identification(1) complies by IR
(2) complies by UV
Conforms
Conforms
Residue on IgnitionNot more than 0.1%0.05%
Loss on dryingNot more than 0.50.1%
Chromatographic
purity
Total impurities not more than 2.0%<2.0%
AssayIt should contain 97.0% to 102.0% of C18H24O3 calculated on dried basis98.4%
Particle sizeIt should be 90% below 30μmConforms
ConclusionConforms to USP36

 

 

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