INCI NAME:Q10 10% Coq10

Molecular formula:C59H90O4

Molecular weight:863.34

CAS:303-98-0

Quality standard: CP2010/BP/EP/ JP/USP

Character:Orange Powder

Co-Enzyme Q10 is a naturally occurring fat-soluble vitamin-like quinone commonly known as, CoQ10. It is also called ubiquinone as it is ubiquitous or present in all eukaryotic cells. Chemically CoQ10 is 2, 3 dimethoxy-5 methyl-6 decaprenyl benzoquinon. The functional group in CoQ10 is the quinone ring. By reduction of the quinone to quinol (H2 CoQ10) a carrier of protons and electrons is produced.

Other Sources:

Other sources of CoQ10 are soya oil, fish oils, peanuts, sardines and mackerel.

Dietary intake of CoQ10 is 2-5 mg/day, which is always inadequate to provide levels in the body required to be beneficial in pathological states.

Potential clinical uses for Coenzyme Q10

Arteriosclerosis

Ischemic heart disease

Chronic heart failure (for both systolic and diastolic heart failure)

Hypertrophiccardiomyopathy

Cardiovascular surgery

Hypertension

Arrhythmias,

Valvular heart diseases,

Toxin-induced cardiomyopathy

Including statin cardiomyopathy and meniere's disease.

Mechanism of action (MOA) The possible therapeutic mechanisms of action of coenzyme Q10 in cardiovascular diseases are as follows: Improvement of cardiac bioenergetics Direct free radical scavenger and antioxidant effect Correction of coenzyme Q10 deficiency state Improved endothelial function and vasodilatory effect

Direct membrane-stabilizing activity due to phospholipid-protein interactions Preservation of myocardial Na+-K+ ATPase activity Stabilization of integrity of Ca2+-dependent slow channels Correction of mitochondrial "leak" of electrons during oxidative respiration Induction of DT diaphorase Possible effects on prostaglandin metabolism Antiviscosity effect Altering the immune response

-          Improvement of cardiac bioenergetics

-          Antioxidant action

-          Endothelial function

-          Membrane stabilization and fluidity

-          Reduction in proinflammatory cytokines

Dosage:

The dosage of CoQ10 used in clinical trials has evolved over the past 20 years.

Capsules/tablets comes in different dosage formations: 25mg, 30 mg, 50 mg, 75 mg, and 100mg.

• Congestive Heart Failure (CHF): 50 - 100 mg in two or three divided doses.

• Angina: 150 - 600 mg in two or three divided doses.

▪ HTN: 75-360mg/day in divided doses.

• Mitochondria Disorders: 400 - 600mg/day in divided doses.

▪ Coenzyme Q10 deficiency: 150mg/day.

▪ Migraines prophylaxis: 150mg/day.

▪ Gum disease: 25 mg two times a day.

• Parkinson Disease: 1200mg/day.

Safety:

For most adults, coenzyme Q10 is tolerated well and safe. However, it can cause some mild side effects including stomach upset, loss of appetite, nausea, and diarrhea. It also might lower blood pressure, so it is recommended to monitor blood pressure closely of those with low blood pressure. Dividing the total daily dose into two or three smaller doses a day can help reduce side effects.