CAS 157115-85-0 Noopept Powder High Quality Gvs- 111 Good Feedback From Customers
China CAS 157115-85-0 Noopept Powder High Quality Gvs-111 Good Feedback From Customers, Find details about China 157115-85-0, Noopept from CAS 157115-85-0 Noopept Powder High Quality Gvs-111 Good Feedback From Customers
Basic Info.
Model NO.
157115-85-0
MOQ
1
Product Name
Noopept
CAS No.
157115-85-0
Mf
C17h22n2o4
MW
318.368
Use
Polypeptide
Other Name
Gvs-111
Key Word1
Noopept
Key Word2
Noopept Powder
Key Word3
Noopept Supplier
Key Word4
Noopept Factory
Key Word5
Noopept Manufacturer
Key Word6
Noopept China
Trademark
Hubei Aoks
Transport Package
Bottles or Drums
Specification
99%
Origin
China
HS Code
2933990090
Model NO.
157115-85-0
MOQ
1
Product Name
Noopept
CAS No.
157115-85-0
Mf
C17h22n2o4
MW
318.368
Use
Polypeptide
Other Name
Gvs-111
Key Word1
Noopept
Key Word2
Noopept Powder
Key Word3
Noopept Supplier
Key Word4
Noopept Factory
Key Word5
Noopept Manufacturer
Key Word6
Noopept China
Trademark
Hubei Aoks
Transport Package
Bottles or Drums
Specification
99%
Origin
China
HS Code
2933990090
Product Desciption
Free of customs clearance!!We will ship by special line that shipping company do custom clearance and deliver to door.100% pass customs!
Product details:
Use of noopept
Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.IC50 Value:Target: in vitro: Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM). GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action.in vivo: N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively).Toxicity: Noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity. Clinical trial: Discontinued
Packing&Shipping
Packing
Shpping
About Us:
HUBEI AOKS BIO-TECH CO.,LTD is located in Hubei province of China.We specialized in active pharmaceutical ingredient,pharmaceutical intermediates,veterinary drugs and agrochemicals.
We have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling.Our products are exported to more than 60 countries overseas, 80% of which are exported to Europe and America, and 20% to Southeast Asia, the Middle East, South Africa and other regions. Because of excellent quality and after-sales service, our company has gained a good reputation at home and abroad.
"Quality Best,Customer First" is what we adhering,sincerely looking forward to establish long-term and mutual beneficial business relationship with worldwide customers.
2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions.
5.We could make our price discount if you place a substantial order with us.
2.Fast shipment by reputed shipping line.
3.Packing with pallet as buyer's special request.
4.Best service after shipment with e mail.
5.Cargoes together with container sales service available.
6.Full experience for Canada & Japan export.
7.Cargoes photo before and after loading into container.
8.Raw materials from Chinese origin.
F.A.Q
Product details:
| Product Name | Noopept |
|---|---|
| Cas No. | 157115-85-0 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 547.3±50.0 °C at 760 mmHg |
| Melting Point | 94.0 to 98.0 °C |
| Molecular Formula | C17H22N2O4 |
| Molecular Weight | 318.368 |
| Flash Point | 284.8±30.1 °C |
| Exact Mass | 318.157959 |
| PSA | 75.71000 |
| LogP | 1.28 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.549 |
Use of noopept
Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.IC50 Value:Target: in vitro: Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM). GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action.in vivo: N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively).Toxicity: Noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity. Clinical trial: Discontinued
Packing&Shipping
Packing
Shpping
About Us:
HUBEI AOKS BIO-TECH CO.,LTD is located in Hubei province of China.We specialized in active pharmaceutical ingredient,pharmaceutical intermediates,veterinary drugs and agrochemicals.
We have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling.Our products are exported to more than 60 countries overseas, 80% of which are exported to Europe and America, and 20% to Southeast Asia, the Middle East, South Africa and other regions. Because of excellent quality and after-sales service, our company has gained a good reputation at home and abroad.
"Quality Best,Customer First" is what we adhering,sincerely looking forward to establish long-term and mutual beneficial business relationship with worldwide customers.
Our Service
1.Cooperate with research institutions, we strictly control the process from raw material to finished product.2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions.
5.We could make our price discount if you place a substantial order with us.
Why Choose Us?
1.Full experience of large numbers containers loading in Chinese sea port.2.Fast shipment by reputed shipping line.
3.Packing with pallet as buyer's special request.
4.Best service after shipment with e mail.
5.Cargoes together with container sales service available.
6.Full experience for Canada & Japan export.
7.Cargoes photo before and after loading into container.
8.Raw materials from Chinese origin.
F.A.Q
1:Can I get some samples before bulk order?
Yes, we can supply the free sample, but the shipping cost be paid by customers.
2: How to start orders or make payments?
PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union, L/C, Alibaba trade assurance, Moneygram or Bitcoin.
3: What's your MOQ?
Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid. It depends on the product.
4: How about delivery leadtime?
Delivery lead time: About 3-5 workdays after payment confirmed.
5: How to contact us ?
You can chat with us by Trademanager,WhatsApp&Skype Online. You can dial our telephone directly or send E-mail to us and you will get our reply
6: How to confirm the Product Quality before placing orders?
You can get samples for the product you interest. Or you can send us your product specifications and requests,we will manufacture the products according to your requests.
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