China Topical Anesthetic Drugs Levobupivacaine Hydrochloride/HCl CAS: 27262-48-2, Find details about China Levobupivacaine HCl, Levobupivacaine HCl Powder from Topical Anesthetic Drugs Levobupivacaine Hydrochloride/HCl CAS: 27262-48-2
Product Name | Levobupivacaine hydrochloride |
CAS | 27262-48-2 |
MF | C18H29ClN2O |
MW | 324.89 |
Purity | 99% |
Appearance | white crystalline powder |
Usage | Local anaesthetics |
Categories | Pharmaceutical Raw Materials;Active Pharmaceutical Ingredients;API;Inhibitors |
Levobupivacaine Hydrochloride is the hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property.
Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.
Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AbbVie under the trade name Chirocaine.
Test | Analysis Standard | Results | |
Melting Point | 139~145ºC | 139.5~142.5ºC | |
Specific Rotation | +55°~ +58° | +57.2° | |
Loss On Drying | 0.32% | ≤1.0% | |
Residue On Ignition | 0.03% | ≤0.2% | |
Assay | 99.36% | 98.0%~101.0% | |
Conclusion | Be Conform With Enterprise Standard |
Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine. Bupivacaine is an amide-type local anaesthetic. Although it blocks neuro transmission, its membrane stabilising action also affects the myocardium. This can cause fatal cardiotoxicity. As bupivacaine is widely used in surgery and obstetrics, attempts have been made to develop a safer long-acting local anaesthetic.
The bupivacaine molecule is a racemic compound. Levobupivacaine is the S-enantiomer of bupivacaine and is thought to have less cardiotoxic potential than the R-enantiomer. The pharmacokinetic parameters of levobupivacaine are similar to those of bupivacaine.
Levobupivacaine has been studied in surgical anaesthesia and for pain management. It can be used for local infiltration, epidural, intrathecal and peripheral nerve blocks. For epidural analgesia it can be given with clonidine. Double-blind comparisons of levobupivacaine and bupivacaine show that their anaesthetic effects are similar.
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Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales.
Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world.
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