Supply Top Quality Pharmaceutical Peptides 10mg Dsip Hormones Dsip CAS 62568-57-4

Major Product: Peptides; Nootropics; Fine Chemicals

Factory: Almondsea which is specialized in custom synthesis and R&D in APIs and pharmaceutical intermediates, is located in Jiangsu, China. We have established long-term cooperation with Shanghai Institute of Organic Chemistry, Jiangsu University etc since 2012. 
As a special team in organic chemistry and medical chemistry, we also support the technology of R&D on new product. We have strong advantages on the process research and product R&D, pay attention to researching and developing new technology which is self-owned intellectual property right. We are special at developing Drug for the respiratory, antidepressant, antivirus, etc. We have completed R&D of more than 20 APIs and intermediates after the company founded.

Product Name:Delta sleep-inducing peptide,DSIP
DSIP CAS NO:62568-57-4
DSIP Molecular Formula:C35H48N10O15
DSIP Molecular Weight:848.81
DSIP Purity:99%
DSIP Specification:2mg/vial
DSIP Grade:pharmaceutical grade

DSIP Function
Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies

Roles in endocrine regulation
Decreases basal corticotropin level and blocks its release.
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.

Structure and Interactions
DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C
It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[5] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids.
Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).GILZ can be induced by Dexame. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.