99% Purity Minoxidil Raw Material Powder Minoxidil Hair Regrowth Minoxidil

China 99% Purity Minoxidil Raw Material Powder Minoxidil Hair Regrowth Minoxidil, Find details about China Minoxidil, Raw Powder Minoxidil from 99% Purity Minoxidil Raw Material Powder Minoxidil Hair Regrowth Minoxidil

Basic Info.

Model NO.

D-sung Minoxidil

Product Name

Minoxidil

Name

Minoxidil Powder

CAS

38304-91-5

Appearance

White Crystalline Powder

Color

White

Grade

Minoxidil

Assay

HPLC 99%

Molecular Formula

C9h15n5o

Application

Anti Hair Loss

Specific

COA

Test Method

HPLC

Shelf Life

2 Years

Einecs

253-874-2

Density

1.52g/cm3

Melting Point

272-274°c (DEC.)(Lit.)

Trademark

D-sung

Transport Package

Foil Bag/Carton/Drum

Specification

99%

Origin

Shaanxi Xi′an

Model NO.

D-sung Minoxidil

Product Name

Minoxidil

Name

Minoxidil Powder

CAS

38304-91-5

Appearance

White Crystalline Powder

Color

White

Grade

Minoxidil

Assay

HPLC 99%

Molecular Formula

C9h15n5o

Application

Anti Hair Loss

Specific

COA

Test Method

HPLC

Shelf Life

2 Years

Einecs

253-874-2

Density

1.52g/cm3

Melting Point

272-274°c (DEC.)(Lit.)

Trademark

D-sung

Transport Package

Foil Bag/Carton/Drum

Specification

99%

Origin

Shaanxi Xi′an

Product Desciption

99% Purity Minoxidil Raw Material Powder Minoxidil Hair Regrowth Minoxidil

99% Purity Minoxidil Raw Material Powder Minoxidil Hair Regrowth Minoxidil

Product Name	Minoxidil
CAS	38304-91-5
Einecs No	253-874-2
Appearance	White to off white crystalline powder
MF	C9H15N5O
Molecular Weight	209.25
Purity	99%
Shelf Life	24 Months

Minoxidil, whose chemical name is 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide, is an organic substance that is white or off-white crystalline powder. Clinically, as a potassium channel opener, it can directly relax vascular smooth muscle, and has a strong arterial expansion effect, which reduces peripheral resistance and blood pressure without affecting the volume of blood vessels, so it can promote venous return. At the same time, due to reflex regulation and positive frequency effects, cardiac output and heart rate can be increased, but it does not cause orthostatic hypotension.

(1) Stimulate the proliferation and differentiation of hair follicle epithelial cells: Culture normal human hair follicle epithelial cells in different concentrations of minoxidil. Minoxidil can stimulate the proliferation of hair follicle epithelial cells at micromolar concentrations. Minoxidil sulfate is an active metabolite that stimulates hair growth, and the activity of sulfate transferase is higher in hair follicles than in epidermis and dermis. The in vitro histological culture of rat tentacles hair follicles and the experiment of synthesizing hair keratin with 35s-labeled cysteine confirmed that both minoxidil and its sulfate have a hair growth effect. In vitro experiments show that the effect of minoxidil sulfate is 14 times that of minoxidil. If the inhibitor of sulfotransferase or sulfuric acid scavenger is added, it can inhibit the hair growth effect of minoxidil, but it has no effect on sulfuric acid metabolites. The effect has no effect. Animal experiments show that Minoxidil can increase the synthesis of dermal papilla, hair matrix, outer hair root sheath and fibrocytes around the hair, thereby prolonging the hair growth period and promoting the transformation of a hair to terminal hair.
(2) Promote angiogenesis: increase local blood supply: hair growth depends on the vascular network of the dermal papilla to provide nutrients. In different hair growth cycles, the expression of vascular endothelial growth factor mRNA is different, and the growth phase vascular endothelial growth factor mRNA is in the dermis. It is strongly expressed in papillary cells, but less expressed in the anagen phase and telogen phase. Experiments have shown that minoxidil increases the expression of vascular endothelial growth factor mRNA and its protein in a dose-dependent manner, thereby promoting the formation of blood vessels in the dermal papilla and increasing local blood supply.
(3) Opening potassium channels: The opening of potassium channels is an important step in regulating hair growth. In vivo and in vitro experiments in animal models have shown that minoxidil is a potassium channel activator, which can increase the permeability of potassium ions and prevent calcium ions from flowing into humans. In the cell, the result is a decrease in the concentration of free calcium ions in the cell, and when calcium ions are present, epidermal growth factor inhibits hair growth.