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Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.Veterinarians also use xylazine as an emetic, especially in cats.

In veterinary anesthesia, xylazine is often used in combination . It is sold under many brand names worldwide, most notably the Bayer brand name Rompun.It is also marketed as Anased, Sedazine, and The drug interactions vary with different animals.

Xylazine is often used as a sedative, muscle relaxant, and analgesic. It is frequently used in the treatment of tetanus.

Xylazine is very similar to drugs such as phenothiazine, tricyclic antidepressants, and clonidine. As an anesthetic, it is typically used in conjunction .Xylazine appears to reduce sensitivity to insuli and glucose uptake in humans.Yohimbine has been used to decrease glucose levels to a healthy level. In clinical settings, Yohimbine can reverse the adverse effects of xylazine if administered intravenously at a dosage of 0.5 mL / 20 pounds shortly after xylazine administration.

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