HOPSON n-Butyl cyanoacrylate adhesive, a cyanoacrylate ester, is a butyl ester of 2-cyano-2-propenoic acid. It is a clear colorless liquid with a sharp, irritating odor. It is water resistant. Its chief use is as the main component of medical cyanoacrylate glues and surgical glue.
The closure of the wound or cut is quick (about 30 to 45 seconds) and the product has inherently some valuable bacteriostatic properties. The cosmetic outcome of the closure is comparable or generally better than an equivalent suture substitute with least amount of scarring visible after three to six months.
The medical applications of butyl cyanoacrylate include its use as an adhesive for lacerati
ons of the skin and in the treatment of bleeding from vascular structures. Butyl cyanoacrylate has been used to treat arteriovenous malformations by application of the glue into the abnormality through angiography.
In gastroenterology, butyl cyanoacrylate is used to treat bleeding gastric varices, which are dilated veins that occur in the setting of liver cirrhosis or thrombosis of the splenic vein. The gastric varices are accessed by endoscopy, which uses a flexible fibre-optic camera to enter the stomach. They are injected with a catheter needle inserted into the varix through the endoscope. Other sites of varices, including esophageal varices, duodenal varices and colonic varices. Gastric varices have also been obliterated with recurrent injection treatment with butyl cyanoacrylate.
Feature:
Chemical Abstracts Service (CAS) Registry Number: 6606-65-1
Chemical Description and Physical Properties: Clear colorless liquid with a sharp, irritating pungent odor. Insoluble in water.
Molecular formula: C8H11NO2
Molecular weight: 153.18
Boiling point: 68° C
Density: 0.989 @ 20° C
Vapor pressure: <0.5 mm @ 20° C
Flash point: >80° C (closed cap)
Health Factors
Potential symptoms: Eye, nose, and throat irritation; Coughing; Wheezing; Laryngitis; Shortness of breath
Health Effects: Irritation-Eyes, Nose, Throat, Skin-Mild (HE16); CNS effects (HE7)
Affected organs: Eyes, skin, respiratory system