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Description | Synephrine (Oxedrine) is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra.[1][2]. |
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Related Catalog | Research Areas >> Endocrinology |
Target | α-adrenergic and β-adrenergic[1] |
In Vivo | Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine[2]. Animal Model: Portal vein ligation (PVL) or bile duct ligation (BDL) rats[2] Dosage: 1 mg/kg per 12 hours Administration: Oral gavage; for 8 days Result: The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced. |
References | [1]. Thomas JE, et al. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009;36(6):586-90. [2]. Huang YT, et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb;85(2):183-8. |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 341.1±27.0 °C at 760 mmHg |
Melting Point | 187 °C (dec.)(lit.) |
Molecular Formula | C9H13NO2 |
Molecular Weight | 167.205 |
Flash Point | 163.4±14.3 °C |
Exact Mass | 167.094635 |
PSA | 52.49000 |
LogP | -0.03 |
Vapour Pressure | 0.0±0.8 mmHg at 25°C |
Index of Refraction | 1.572 |
Storage condition | 2-8°C |