Pharmaceutical Raw Mupirocin Powder CAS 12650-69-0 for Antibiotic

2. Description of Mupirocin:


Mupirocin (trade names Bactroban, Centany) is an antibiotic. It is used topically and is effective against Gram-positive bacteria, including MRSA.Mupirocin is inactive for most anaerobic bacteria, mycobacteria, mycoplasma, chlamydia, yeast and fungi.

Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations.It is of the monoxycarbolic acid class.Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. Also present in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8,pseudomonic acid C with a double bond between C10 and C11, instead of the epoxide of PA-A,and pseudomonic acid D with a double bond at C4` and C5` in the 9-hydroxy-nonanoic acid portion of mupirocin.


3. Mupirocin Medical Uses:


Mupirocin is used as a topical treatment for bacterial skin infections, for example, furuncle,impetigo, open wounds, etc. It is also useful in the treatment of methicillin-resistantStaphylococcus aureus (MRSA), which is a significant cause of death in hospitalized patients having received systemic antibiotic therapy. It is suggested, however, that mupirocin cannot be used for extended periods of time, or indiscriminately, as resistance does develop, and could, if it becomes widespread, destroy mupirocin's value as a treatment for MRSA. It may also result in overgrowth of non-susceptible organisms.


4. How to Use Mupirocin:


Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the preparation prescribed for you.

Wash your hands before you use the cream/ointment. Use a cotton wool pad to apply a small amount to the infected area. It may sting a little when you first apply it but this should soon pass. You can use a sticking plaster or dressing to protect the treated area if needed. You should use mupirocin two or three times a day unless your doctor has told you otherwise. Do not use it for longer than ten days.

For mupirocin to work properly it should be applied regularly. If you forget to use it at your usual time, apply it as soon as you remember and then go on as before.


5. Dosage:


For the treatment of impetigo, a small amount of the ointment is applied to the affected area, usually three times daily (every 8 hours). The area may be covered with a sterile gauze dressing. If there is no improvement in 3-5 days, the physician should be contacted to re-examine the infected area. For other skin infections, the cream is applied to the affected area 3 times a day for 10 days, and the doctor should be contacted as well if there is no improvement after 3-5 days.

When mupirocin is used for treating intranasal Staphylococcus aureus that are resistant to other antibiotics, patients who are age 12 years and older require the application of about half of the ointment from a single-use tube of ointment into one nostril and the other half into the other nostril. This treatment is repeated twice daily for 5 days. Currently, there is not enough information to recommend use of mupirocin in children younger than 12 years of age.

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Pharmaceutical Raw Mupirocin Powder CAS 12650-69-0 for Antibiotic