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WHAT IS CJC-1295?

CJC-1295 is a synthetic GHRH (GH releasing hormone) analogue made up of 30 amino acids. It has been found to be highly effective with regards to the increase of GH secretion and 1GF-1 without negatively affecting the pulsatility of GH secretion.

CJC-1295 is often combined with Ipamorelin due to its enhanced specificity as a GHRH. This peptide generates similar increases in GH secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated and perfect when combined with Ipamorelin.

Gland Stimulated: Pituitary

BENEFITS OF CJC-1295: 

• Increased GH secretion and 1GF-1 Levels with no increase in prolactin
• Increased Body Weight and Length through increased protein synthesis
• Increased Muscle Growth
• Increased Bone Density
• Improved Immune Function
• Improved Cognition and Memory
• Increased Collagen Production
• Increased Fat Loss
• Increased Cellular Repair and Regeneration

CJC-1295 also promotes slow wave deep sleep, which is responsible for the highest level of muscle growth and memory retention and rejuvenation 

Two types of CJC 1295:

GHRH (GH releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).

The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases it's half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.

The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.