China Anti-Cancer 99% Purity CAS 159351-69-6 Everolimus Powder, Find details about China Everolimus, Pharmaceutical Intermediate from Anti-Cancer 99% Purity CAS 159351-69-6 Everolimus Powder
Name | Everolimus powder CAS 159351-69-6 |
CAS No | CAS 159351-69-6 |
Appearance | white powder |
Molecular Formula | C53H83NO14 |
Molecular Weight | 914.18 |
Assay | 98%min |
Everolimus (RAD001) is an orally active derivative of rapamycin that inhibits Ser / Thr kinase mTOR [1]. In sensitive mouse B16/BL6 melanoma (IC50, 0.7 nM) and insensitive human cervical KB-31 (IC50, 1,778 nM), the antiproliferative concentration of everolimus resulted in a total of S6K1 and substrate S6. Dephosphorylation and changes in mobility. 4E-BP1, indicating a decrease in phosphorylation status [2]. Everolimus showed dose-dependent inhibition in total cells and stem cells from the BT474 cell line and primary breast cancer cells, albeit with varying degrees of growth inhibition. Compared with total cells, everolimus had a poor inhibitory effect on stem cell growth at all concentrations tested (P < 0.001). The IC50 values of everolimus against BT474 and primary CSC were 2,054 and 3,227 nM, respectively, or 29 and 21 times the IC50 values of their respective total cells, respectively.
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