What is Huperzine A?

Huperzia serrata ( Qian Ceng Ta/Jin Bu Huan) is a plant known as a firmoss which contains the acetylcholinesterase inhibitor huperzine A. It is widely distributed over-the-counter as a nootropic and dietary supplement.

This species is native to China, India and southeast Asia.

Huperzine A is a reversible acetylcholinesterase inhibitor and NMDA receptor antagonist that crosses the blood-brain barrier. A 2013 meta-analysis found that huperzine A may be efficacious in improving cognitive function, global clinical status, and activities of daily living for individuals with Alzheimer's disease.

Huperzine A is also marketed as a dietary supplement with claims made for its ability to improve memory and mental function. Huperzine A may also have a possible role in the treatment of myasthenia gravis.