Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by Inhibition of P53 and Phosphorylated Hsp27 CAS: 53123-88-9
China Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by Inhibition of P53 and Phosphorylated Hsp27 CAS: 53123-88-9, Find details about China Rapamycin, Rapamune from Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by Inhibition of P53 and Phosphorylated Hsp27 CAS: 53123-88-9
Basic Info.
Model NO.
Rapamycin
Product Name
Rapamycin
Trade Name
Rapamune
HPLC
99.5% HPLC
Shelf Life
24month
Storage
Room Temperature Away From Light
Application
Novel Immunosuppressants
Shipping
FedEx DHL UPS TNT Fastway
Shipping Items
DDP/CIF
Grade
Injection Grade
Trademark
Niche
Transport Package
10g, 100g, 1kg
Specification
10g, 100g, 1kg
Origin
China
HS Code
2933990788
Model NO.
Rapamycin
Product Name
Rapamycin
Trade Name
Rapamune
HPLC
99.5% HPLC
Shelf Life
24month
Storage
Room Temperature Away From Light
Application
Novel Immunosuppressants
Shipping
FedEx DHL UPS TNT Fastway
Shipping Items
DDP/CIF
Grade
Injection Grade
Trademark
Niche
Transport Package
10g, 100g, 1kg
Specification
10g, 100g, 1kg
Origin
China
HS Code
2933990788
Product Desciption
Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by Inhibition of p53 and Phosphorylated HSP27 CAS:53123-88-9
Description:
What is Rapamycin?
Rapamycin (Sirolimus) slows aging, extends life span, and prevents age-related diseases, including diabetic complications such as retinopathy. Puzzlingly, rapamycin can induce insuli sensitivity, but may also induce insuli resistance or glucose intolerance without insuli resistance. This mirrors the effect of fasting and very low calorie diets, which improve insuli sensitivity and reverse type 2 diabetes, but also can cause a form of glucose intolerance known as benevolent pseudo-diabetes. There is no indication that starvation (benevolent) pseudo-diabetes is detrimental. By contrast, it is associated with better health and life extension. In transplant patients, a weak association between rapamycin/everolimus use and hyperglycemia is mostly due to a drug interaction with calcineurin inhibitors. When it occurs in cancer patients, the hyperglycemia is mild and reversible. No hyperglycemic effects of rapamycin/everolimus have been detected in healthy people. For antiaging purposes, rapamycin/everolimus can be administrated intermittently (e.g., once a week) in combination with intermittent carbohydrate restriction, physical exercise, and metformin.
Rapamycin (known clinically as Sirolimus or Rapamune) and its analog, RAD001 (everolimus), are FDA-approved drugs widely used in humans. Rapamycin, a natural product, is older, cheaper, better studied, and more available than everolimus, though everolimus is increasingly being used clinically. Both drugs inhibit mTOR complex 1 (mTORC1) by the same mechanism, and their biological effects are identical at equipotent concentrations, taking into account that rapamycin is slightly more potent and has a longer half-life than everolimus1. Although the difference in their pharmacokinetics within the human body has been well characterized, that difference has not yet been exploited for clinical purposes, and neither drug is considered superior to the other. As a result, studies with these two drugs complement one another: what has been shown for rapamycin is largely applicable to everolimus and vice versa (at equivalent concentrations). We will use the term rapalogs to encompass both drugs rather than everolimus alone.
Typical Properties:
Novel immunosuppressants
Related Products :
Service
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.
Advantage
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
3. After-Sale Service:
1)International Authorized Third-Party Test For The Products You Demand.
2)60 Days Warranty of quality of goods.
Q&A
Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples.
Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: What's the MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.
Q4: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q5: How do you treat quality complaint?
A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to customer.
In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Detailed Product Information
Product Name: Rapamycin
Brand Name: Rapamune
CAS No.: 53123-88-9
Molecular Formula: C51H79NO13
Molecular Weight: 914.19g/mol
Purity : 99%
Appearance: White Crystalline Powder
Typical use:Novel immunosuppressants
Standard Packing : 1gram,10gram,100gram
Shelf Life :2 years
Storage:Room temperature away from light
Product Name: Rapamycin
Brand Name: Rapamune
CAS No.: 53123-88-9
Molecular Formula: C51H79NO13
Molecular Weight: 914.19g/mol
Purity : 99%
Appearance: White Crystalline Powder
Typical use:Novel immunosuppressants
Standard Packing : 1gram,10gram,100gram
Shelf Life :2 years
Storage:Room temperature away from light
Description:
What is Rapamycin?
Rapamycin (Sirolimus) slows aging, extends life span, and prevents age-related diseases, including diabetic complications such as retinopathy. Puzzlingly, rapamycin can induce insuli sensitivity, but may also induce insuli resistance or glucose intolerance without insuli resistance. This mirrors the effect of fasting and very low calorie diets, which improve insuli sensitivity and reverse type 2 diabetes, but also can cause a form of glucose intolerance known as benevolent pseudo-diabetes. There is no indication that starvation (benevolent) pseudo-diabetes is detrimental. By contrast, it is associated with better health and life extension. In transplant patients, a weak association between rapamycin/everolimus use and hyperglycemia is mostly due to a drug interaction with calcineurin inhibitors. When it occurs in cancer patients, the hyperglycemia is mild and reversible. No hyperglycemic effects of rapamycin/everolimus have been detected in healthy people. For antiaging purposes, rapamycin/everolimus can be administrated intermittently (e.g., once a week) in combination with intermittent carbohydrate restriction, physical exercise, and metformin.
Rapamycin (known clinically as Sirolimus or Rapamune) and its analog, RAD001 (everolimus), are FDA-approved drugs widely used in humans. Rapamycin, a natural product, is older, cheaper, better studied, and more available than everolimus, though everolimus is increasingly being used clinically. Both drugs inhibit mTOR complex 1 (mTORC1) by the same mechanism, and their biological effects are identical at equipotent concentrations, taking into account that rapamycin is slightly more potent and has a longer half-life than everolimus1. Although the difference in their pharmacokinetics within the human body has been well characterized, that difference has not yet been exploited for clinical purposes, and neither drug is considered superior to the other. As a result, studies with these two drugs complement one another: what has been shown for rapamycin is largely applicable to everolimus and vice versa (at equivalent concentrations). We will use the term rapalogs to encompass both drugs rather than everolimus alone.
Typical Properties:
Novel immunosuppressants
Related Products :
| Item Name | CAS No. | Item Name | CAS No. |
| PRL-8-53 | 51352-87-5 | NSI-189 Phosphate | 1270138-40-3 |
| IDRA-21 | 22503-72-6 | Unifiram/DM-232 | 272786-64-8 |
| Noopept/GVS-111 | 157115-85-0 | Fasoracetam | 110958-19-5 |
| Pramiracetam | 68497-62-1 | Piracetam | 7491-74-9 |
| Carphedo | 77472-70-9 | Phenylpiracetam Hydrazide | 77472-71-0 |
| Oxiracetam | 62613-82-5 | Aniracetam | 72432-10-1 |
| Coluracetam | 135463-81-9 | Nefiracetam | 77191-36-7 |
| Sunifiram | 314728-85-3 | Phenibut | 3060-41-1 |
| 63547-13-7 | Compound 7P | 1890208-58-8 | |
| Caffeic Acid Phenethylester | 104594-70-9 | CRL-40,941 | 90212-80-9 |
| Tianeptine Sulfate/THM | 1224690-84-9 | CRL-40,940 | 90280-13-0 |
| Tianeptine sodium | 30123-17-2 | 6-Paradol | 27113-22-0 |
| Palmitoylethanolamide/PEA | 544-31-0 | N-Methyl-D-Aspartic Acid/NMDA | 6384-92-5 |
| Nooglutyl | 112193-35-8 | L-Alanyl-L-Glutamine | 39537-23-0 |
| 5-HTP | 4350-09-8 | J-147 | 1146963-51-0 |
Service
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.
Advantage
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
3. After-Sale Service:
1)International Authorized Third-Party Test For The Products You Demand.
2)60 Days Warranty of quality of goods.
Q&A
Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples.
Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: What's the MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.
Q4: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q5: How do you treat quality complaint?
A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to customer.
In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
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