High Purity Rapamycin Sirolimus CAS No. 53123-88-9

China High Purity Rapamycin Sirolimus CAS No. 53123-88-9, Find details about China CAS No. 53123-88-9, Sirolimus Rapamycin from High Purity Rapamycin Sirolimus CAS No. 53123-88-9

Model NO.
DY2020
Einecs
610-965-5
Product Name
Rapamycin Powder
Grade Standard
Food Grade, Medicine Grade
Appearance
White Powder
Shelf Life
2 Year Properly
Trademark
Dongyao
Transport Package
Bag and Barrel
Specification
1kg 5kg 10kg 25kg
Origin
He Nan
HS Code
29349990
Model NO.
DY2020
Einecs
610-965-5
Product Name
Rapamycin Powder
Grade Standard
Food Grade, Medicine Grade
Appearance
White Powder
Shelf Life
2 Year Properly
Trademark
Dongyao
Transport Package
Bag and Barrel
Specification
1kg 5kg 10kg 25kg
Origin
He Nan
HS Code
29349990
product description 

Rapamycin is a macrolide compound obtained from streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. 


Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.

Function

It is used to coat coronary stents, prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It inhibits activation of T cells and B cells by reducing the production of interleukin-2 (IL-2).

Application

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

Company Introduction
High Purity Rapamycin Sirolimus CAS No. 53123-88-9

Packing
25kgs/Fiber drum outside and plastic bag inside; 

1-25kgs packaging, aluminium Foil bag outside and double plastic bag inside;
Delivery Detail: within 3 days when get the payment
Shipping: We have  Professional  shipping agent, based on customers ' demand for transport
By express: FEDEX,DHL,EMS ,UPS,TNT ect.
By SEA and By AIR

Our Service:

24 hours online 
1.Any inquiries will be replied with in 12 hours.

2.Dedication to quatity,supply& service.

3.Strictly on selecting raw meterials.

4.Reasonable & competitive price ,fast lead time.

5.Smple order in stock and one week for bulk production.

6. We have strong cooperation with FEDEX,TNT,DHL,EMS,or you also can choose your own shipping agent..

High Purity Rapamycin Sirolimus CAS No. 53123-88-9