OEA, Oleoyl ethanolamide or oleoylethanolamide, is a naturally occurring lipid that binds with high affinity to the PPAR-α, that may have effects on preventing and curing atherosclerosis. Report shows OEA can turn off the switch in the central nervous system for hunger, it is conducive to modulate food intake and weight management. Moreover, OEA also can be used for Beneficial effect on analgesic and Anti- depression.