China Hair Loss Solution CB-03-01//Breezula//17alpha-Propionate CAS No. 19608-29-8, Find details about China 17alpha-Propionate, 19608-29-8 from Hair Loss Solution CB-03-01//Breezula//17alpha-Propionate CAS No. 19608-29-8
Description:
Cortexolone 17α-propionate (developmental code name CB-03-01), or 11-deoxycortisol 17α-propionate, is a synthetic steroidal antiandrogen-specifically, an androgen receptor antagonist - which is used as a topical medication in the treatment of androgen-dependent conditions including acne vulgaris and androgenic alopecia (male-pattern hair loss). It is the C17α propionate ester of 11-deoxycortisol (cortexolone); C17α esters of 11-deoxycortisol were unexpectedly found to possess antiandrogen activity, and cortexolone 17α-propionate was selected for development based on its optimum drug profile.
Function:
CB-03-01 is the drug for the treatment of hair loss dwindled. It has same function and application with RU58841 and Setipiprant.Application:
Cortexolone 17α-propionate (developmental code name CB-03-01), or 11-deoxycortisol 17α-propionate, is a synthetic steroidal antiandrogen-specifically, an androgen receptor antagonist - which is used as a topical medication in the treatment of androgen-dependent conditions including acne vulgaris and androgenic alopecia (male-pattern hair loss). It is the C17α propionate ester of 11-deoxycortisol (cortexolone); C17α esters of 11-deoxycortisol were unexpectedly found to possess antiandrogen activity, and cortexolone 17α-propionate was selected for development based on its optimum drug profile.
COA:
Items | Requirements | Results |
Appearance: | White Powder | White Powder |
Identification |
|
|
HPLC | IR spectra is consistent with CRS | Conforms |
Sulphated Ash | ≤0.1% | 0.01% |
Loss on drying | ≤0.5% | 0.38% |
Related substances | Impurity A ≤0.1% Impurity B ≤0.2% Any other Impurity ≤0.1% All other Impurity A ≤0.2% | <0.1% <0.2% <0.1% <0.2% |
Heavy metal Pb : Cadmium(Cd) : As : Hg: | ≤ 10ppm <1 ppm <0.5 ppm <10ppm < 1 ppm | <10ppm Conforms 0.3ppm Conforms Negative |
Assay | ≥99% | 99.5% |
Conclusion: | The product conforms to BP. |
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