China Supplier CB-03-01 High Quality 99% CB-03-01 Hair Loss Treatment CAS 19608-29-8, Find details about China CB-03-01;, CAS 19608-29-8 from Supplier CB-03-01 High Quality 99% CB-03-01 Hair Loss Treatment CAS 19608-29-8
Product Name | CB-03-01 |
CAS No | 19608-29-8 |
M.F. | C24H34O5 |
Grade | Pharmaceutical Grade |
Color | White powder |
Purity | 99% |
Shelf Life | 2 years |
Description:
Cortexolone 17α-propionate (developmental code name CB-03-01), or 11-deoxycortisol 17α-propionate,
is a synthetic steroidal antiandrogen-specifically, an androgen receptor antagonist - which is used as a
topical medication in the treatment of androgen - dependent conditions including acne vulgaris and rog-
enic alopecia (male-pattern hair loss). It is the C17α propionate ester of 11-deoxycortisol (cortexolone)
; C17α esters of 11-deoxycortisol were unexpectedly found to possess antiandrogen activity, and cortexo
-lone 17α-propionate was selected for development based on its optimum drug profile.
Function
CB-03-01 is the drug for the treatment of hair loss dwindled. It has same function and application with
RU58841 and Setipiprant. CB-03-01 is a molecule that acts at the level of the skin, blocking dihydrot-
estosterone (DHT) from binding to the receptor in the cell. The molecule has a unique mechanism that
acts at the skin surface, and is quickly metabolized to free inactive cortexolone, a substance naturally
found in the body. The molecule has been evaluated in a variety of animal models as well as initial hu-
man trials in Europe. The results of these studies demonstrate that CB-03-01 appears to have potent ac-
tivity without significant local or systemic side effects.
Application
Cortexolone 17α-propionate (developmental code name CB-03-01), or 11-deoxycortisol 17α-propionate,
is a synthetic steroidal antiandrogen-specifically, an androgen receptor antagonist - which is used as a to-
pical medication in the treatment of androgen-dependent conditions including acne vulgaris and androge-
nic alopecia (male-pattern hair loss). It is the C17α propionate ester of 11-deoxycortisol (cortexolone); C-
17α esters of 11-deoxycortisol were unexpectedly found to possess antiandrogen activity, and cortexolone
- 17α-propionate was selected for development based on its optimum drug profile.
Items | Requirements | Results |
Appearance: | White Powder | White Powder |
Identification | ||
HPLC | IR spectra is consistent with CRS | Conforms |
Sulphated Ash | ≤0.1% | 0.01% |
Loss on drying | ≤0.5% | 0.38% |
Related substances | Impurity A ≤0.1% Impurity B ≤0.2% Any other Impurity ≤0.1% All other Impurity A ≤0.2% | <0.1% <0.2% <0.1% <0.2% |
Heavy metal Pb : Cadmium(Cd) : As : Hg: | ≤ 10ppm <1 ppm <0.5 ppm <10ppm < 1 ppm | <10ppm Conforms 0.3ppm Conforms Negative |
Assay | ≥99% | 99.5% |
Conclusion: | The product conforms to BP. |
FAQ
· Q:What is the MOQ?
· A:1kg. But usually, we accept less quantity such as 100g on the condition that sample charge is 100% paid.