China API Powder Simvastatin CAS 79902-63-9 //Proglumide CAS 6620-60-6//Lycorine Hydrochloride CAS 2188-68-3 // Epalrestat CAS 82159-09-9 //CAS 179324-69-7 Bortezomib, Find details about China Simvastatin, CAS 79902-63-9 from API Powder Simvastatin CAS 79902-63-9 //Proglumide CAS 6620-60-6//Lycorine Hydrochloride CAS 2188-68-3 // Epalrestat CAS 82159-09-9 //CAS 179324-69-7 Bortezomib
Introduction
Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S,proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin
proteasome pathway.
Function
Bortezomib Is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma.
In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.
Specification
Item | Specification |
Assay | >98% |
Appearance | White powder |
Odor | Characteristic |
Taste | Characteristic |
Particle Size | NLT 100% Through 80 mesh |
Loss on Drying | <2.0% |
Heavy metals | ≤10ppm |
Arsenic | ≤3ppm |
Lead | ≤3ppm |
<2.0% | |
Total Plate Count | ≤1000cfu/g |
Total Yeast & Mold | ≤100cfu/g |
E.Coli | Negative |
Salmonella | Negative |