Test Items		Specifications
Appearance		White to off-white Powder
Identification	Infrared	Conforms to the Reference Spectrum
	HPLC	The retention time of the major peak corresponds to the reference sample
Water Content(K.F)		3.0% MAX
Sulphated Ash		0.5% MAX.
PH (5% AQUEOUS SOLUTION)		1.0 -2.0
S, S-Isomer (HPLC)		75.0% MIN
SAM-e ION (HPLC)		49.5 - 54.7%
P-Toluenesulfonic Acid		21.0%-24.0%
Content of Sulfate (SO4) (HPLC)		23.5%-26.5%
S-Adenosyl-L-methionine Disulfate Tosylate		95.0%-103%
Related substances(HPLC):
- S-ADENOSYL-L-HOMOCYSTEINE		1.0% MAX.
- ADENINE		1.0% MAX.
- METHYLTHIOADENOSINE		1.5% MAX
- ADENOSINE		1.0% MAX.
- TOTAL IMPURITIES		3.5% MAX.
Heavy Metals		Not more than 10 ppm
LEAD		Not more than 3 ppm
CADMIUM		Not more than 1 ppm
MERCURY		Not more than 0.1 ppm
ARSENIC		Not more than 2 ppm
Microbiology	Total Aerobic Count	≤1000cfu/g
	Yeast and mold count	≤100cfu/g
	E. coli	Absent/10g
	S. aureus	Absent/10g
	Salmonella	Absent/10g

 

1. S-Adenosyl methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from
adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation,
transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions
occur throughout the body, most SAM is produced and consumed in the liver.
2 .The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation
of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the
transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.
3 .In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.
4 .Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine
decarboxylase (EC 4.1.1.50) to form S-adenosyl-5'-3-methylpropylamine. This compound then donates its
n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.
5 .SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and
neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for
the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.
6 .In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled
SAME or SAMe). Some research has indicated that taking SAM on a regular basis help fight depression, liver
disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions
and osteoarthritis. All other indications are not yet proven.

 

 

Hongkong XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

superiority of choosing our company

1, We guarantee deeply analyze and demonstrate, purity more than 99%
2, Factory outlet with priority price & large stock.
3, Special magic vacuum safe package & safe shipping way.All parcel shipments are shipped discreetly and secure under customers' all requests.
4, We promise reship policies if post failed or refund if you need.
5, Rate of passing customs is 99.9% including Russia,Australia and anyother.
6, TNT & UPS & DHL & EMS & Fedex or special line is available for you.Freight fee is all charge by seller.
7,Payment terms: Western Union, Moneygram ,bitcoin ,T/T for your choices.

Our services
1. Customer Satisfaction is our priority and guarantee for the future.
2. We co-develop products and projects with our partners.
3.Place of Origin China with Super quality by reasonable price.
4.When you meet problems in mineral processing, we can provide technical guidance.
5.We will ship the goods that you order from us by EMS, DHL, UPS, or FedEx.We will decided to choose which courier depend on Different countries.To find the best way to delivery the goods for you.
6.We will ship the goods within 5days after get your payments.If you want to cancel or change order, please tell me within 24hours after you finish the payment...So we both can make the best of the bad bargain.
Bulk Order: Shipped via sea or air, it's according to your requirement, delivery time is 7-15days after payment
7.if you have any other questions to consult me.please not hesitate to contact me any times.  We pride ourself on our excellent team of well-known engineers, technological persons and young professional staffs to research and develop new process. We are also dedicated to provide custom synthesis and contract research services to industrial and academic entities on a short or long-term basis. In our lab and pilot-plant, compounds can be manufactured in the quantity from a few grams up to tens of kilos and beyond. we can supply the key intermediates for your project, which short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard.