Cytomegalovirus (CMV) can cause fatal disease

The congenital CMV infection can induce premature birth, abortion, stillbirth and postnatal death; In later stage of pregnancy, the virus of some inapparent infected pregnant women can be activated and excreted from urinary tract and with canal. During childbirth, the newborn will be infected when passing through birth canal, it causes jaundice, hepatosplenomegaly, Thrombocytopenic purport, hemolytic anemia, etc. Guidelines for screening and clinical intervention for congenital cytomegalovirus infection indicates that the prenatal diagnosis of fetal HCMV intrauterine infection can detect the CMV-DNA in the amniotic fluid by QPCR.

In addition, CMV-DNA detection is used to the monitoring of CMV infection in the renal transplant patients, CMV infection is a common early complication and one of the main causes of death after kidney transplantation; It used for the diagnosis and monitoring of CMV infection in blood donors, the clinical manifestations after infection is often subclinical, some can lead to heterotrophic antibody negative mononucleosis; It also used to monitor CMV in HIV patients and immunocompromised persons.