What is Entecavir ?

Entecavir  is a new kind of cyclopentyl acyl guanosine anti-hepatitis b virus drugs with its pharmacological effects similar as entecavir. It is clinically applied to the treatment of adult chronic hepatitis b in which there is active viral replication, increased serum transaminase ALT or active lesions showed from liver histology. 
Entecavir Monohydrate is a kind of analogues of guanine nucleoside which has inhibitory on the polymerase of hepatitis b virus (HBV). It can become active triphosphate salts through phosphorylation. The triphosphate salt has a half-life of 15 hours inside a cell. Through completion with the natural substrates of HBV polymerase, guanine nucleoside triphosphate, entecavir triphosphate can suppress all the three types of activities of the virus polymerase (reverse transcriptase): 
(1) The initiation of HBV polymerase.
(2) The formation of the negative chain of reverse transcription of the pre-genome.
(3) The synthesis of HBVDNA positive chain.