The main reason of color mottle is the maldistribution of endothelin.When the Endothelin Antagonists enter into skin, it can combine with the melanin cytomembrane and then cause endothelin lost its function. 

Function:

It inhibits endothelin to activate tyrosinase, inhibits endothelin to promote the differentiation of melanocytes, and reduces the uneven distribution of pigment, which is 4 times more effective than the general preparation. The uneven distribution of pictin in the skin is the main cause of pigmentation. Endothelin antagonist enters the skin, can bind with the receptor of melanin cell membrane, make endothelin lose its function, achieve the effect of whitening.