China Methylamine Hydrochloride 593-51-1/4-Methoxybenzoic Acid 100-09-4/Sodium Cyanoborohydride 25895-60-7/Diethylstilbestrol 6898-97-1/313-06-4 Estradiol Cypionate, Find details about China Estradiol Cypionate, 313-06-4 from Methylamine Hydrochloride 593-51-1/4-Methoxybenzoic Acid 100-09-4/Sodium Cyanoborohydride 25895-60-7/Diethylstilbestrol 6898-97-1/313-06-4 Estradiol Cypionate
Introduction
Common Name | Estradiol C | ||
---|---|---|---|
CAS Number | 313-06-4 | Molecular Weight | 396.562 |
Density | 1.2±0.1 g/cm3 | Boiling Point | 532.8±50.0 °C at 760 mmHg |
Molecular Formula | C26H36O3 | Melting Point | ≥300 °C(lit.) |
Function
Estradiol cypionate , or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use since. Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, it can be administered less often.Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4-5 days and 7-8 days, respectively.
Application
How to use estradiol cypionate intramuscular.
Read the Patient Information Leaflet if available from your pharmacist before you start using thismedication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.This medication is injected into a muscle as directed by your doctor, usually every 3 to 4 weeks. Thedosage is based on your medical condition and response to treatment.
Specification
Items | Standard | Results |
Description | White crystalline powder | Complies |
Identification | IR HPLC Reactive | Conform with standard IR Conform with standard HPLC Conform |
Solubility | Freely soluble in me,ace,eth and tetrahydrofura.And very soluble in ace | Complies |
Total Impurity | max.0.5% | 0.18% |
Total Unspecified Impurity | max. 0.2% | 0.08% |
Individual unspecified impurlty | max. 0.1% | 0.05% |
Related compound B | max. 0.2% | 0.07% |
Related compound C | max. 0.2% | 0.04% |
Related compound D | max. 0.1% | 0.05% |
Related compound E | max. 0.1% | 0.06% |
Limit of cyc | max. 0.08% | ND |
Limit of ethylacetate | max. 0.1% | 0.07% |
Melting point | 81.0~84.0¡æ | 82.5~83.2ºC |
Water | max. 0.3% | 0.21% |
Residue on ignition | max. 0.1% | 0.07% |
Heavy Metals | max.0.001% | Complies |
Assay(HPLC) | 98.0%~102.0% | 99.8% |
Storage | Cool and dry | |
Conclusion | It complies to USP32 . |