China High Purity Apis Edaravone 89-25-8//Tropicamide 1508-75-4//Hydrocortison Acetate 50-03-3//Phenylbutazone 50-33-9//Uridine 3083-77-0//191217-81-9 Pramipexole, Find details about China Pramipexole, Uridine from High Purity Apis Edaravone 89-25-8//Tropicamide 1508-75-4//Hydrocortison Acetate 50-03-3//Phenylbutazone 50-33-9//Uridine 3083-77-0//191217-81-9 Pramipexole
Introduction
Product Name | Pramipexole dihydrochloride monohydrate |
Appearance | White or off- white crystalline powder |
Assay | 99%min, 98.0% --101.0% |
Test | HPLC |
Certificate | SGS |
CAS | 191217-81-9 |
MF | C10H21Cl2N3OS |
Storage Temperature | Cool Dry Place |
Function
To alleviate the symptoms of Parkinson's disease: Parkinson's disease is due to the movement of brain dopaminergic neuron loss caused by dopamine deficiency, lead to patients with tremor, rigidity and bradykinesia and a series of symptoms. Hydrochlori acid highly selective effects on dopamine D2 and D3 receptor agonist, dopamine release, improve motor symptoms. Research on Shannon display, early Parkinson's disease patients pramipexole monotherapy after, can effectively control the motor symptoms in patients with early stage, to help maintain the ability of daily life. Pramipexole in combination with levodopa can effectively improve the ADL score and motor symptoms in patients with advanced Parkinson's disease score in patients with advanced Parkinson's disease, make life more vibrant.
Application
1. Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome").
2. Pramipexole is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep.
Specification
Test Items | Standard | Test Results | |
Character | Off-white to White Crystalline powder | Off-White Crystalline powder | |
Solubility | Soluble in Water and Methano, slightly soluble in Ethanol (96%), Almost insoluble in Dichloromethan | Complies
| |
Identification | (1)Specific Rotation -67~-69.5°(on anhydrate basis) (2)IR: Meets the requirement. (3) Optical purity Test (4)Chloride Reaction | -68.8 Complies Complies Complies | |
Clarity | Clear, not deeper than Y6. | Complies | |
PH | 2.8~3.4 | 3.15 | |
Related Substances | Impurity A≤0.15% Impurity B≤0.15% Impurity C≤0.15% Unknown single impurity≤0.1% Total Impurity≤0.5% | Not detected 0.04% Not detected 0.05% 0.16% | |
Impurity D | Impurity D≤0. 5% | 0.1% | |
Water | 4.5%~6.5% | 4.9% | |
Heavy metals | ≤10ppm | Complies | |
Sulfate Ash | ≤0.1% | 0.05% | |
Assay (on anhydrate basis) | 99.0%~101.0% | 99.8% | |