7 8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).
7,8-DHF is both orally bioavailable and able to penetrate the blood-brain barrier. A prodrug of 7,8-DHF with greatly improved potency and pharmacokinetics, R7, is under development for the treatment of Alzheimer's disease.

FUNCTION:
1. 7,8-dihydroxyflavone has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome.
2. 7,8-dihydroxyflavone also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents.
3. 7,8-dihydroxyflavone possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against
glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity.

 

1kg/Aluminum foil bag; 
25kg/drum/box or as customer's request 

Based on different qty, we have different Channel for shipment. .. 
Different Countries and different Areas also have difference. 
Package based on customer's request, if customers do not have speical request, then, we will use the safety package we always use. 

We have very professional agents in many countries, U Europe countries (Nethelands, Cz,Poland,SL....and so on), 
Our agents handle all the customs process without any problem to receiver. Whatever 25kg,100kg,500kg,1000kg, We all dare to say Guarantee say yes to you. 
Welcome your inquiry ! 

HUBEI AOKS BIO-TECH CO.,LTD is located in Hubei province of China.We specialized in active pharmaceutical ingredient,pharmaceutical intermediates,veterinary drugs and agrochemicals.

We have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling.Our products are exported to more than 60 countries overseas, 80% of which are exported to Europe and America, and 20% to Southeast Asia, the Middle East, South Africa and other regions. Because of excellent quality and after-sales service, our company has gained a good reputation at home and abroad.

"Quality Best,Customer First" is what we adhering,sincerely looking forward to establish long-term and mutual beneficial business relationship with worldwide customers.

Why Choose US?
1. Selecting raw materials strictly,our products are the highest purity.
2.Reasonable and competitive price. Provide the best and professional service.
3.Fast delivery of the samples ,samples from stock. Reliable shipping way.
4.Full experience of large numbers containers loading in Chinese sea port.
5. Best after-service after shipment .
6. Professional documents for your custom clearance.

Q1:Will you supply samples for testing?
A: Free samples for the quality evaluation for most products, but customers only need to undertake the shipping fee for delivery the samples to your door.

Q2:What's your MOQ?
A: For the high value product, our MOQ starts from 10g,100g and 1kg.

Q3:Which kind of payment terms do you accept?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment
by T/T, Western Union or Alibaba). Bulk order by T/T or L/C.

Q4:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.

Q5:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.