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Introduction
Product Name | Ivermectin |
Appearance | White Powder |
CAS | 70288-86-7 |
Grade Standard | Medicine grade |
Purity: | 99% |
Ivermectin is widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod,
canine intestinal nematodes, ear mites, scabies mites, silk worm and microfilariae, gastrointestinal nematodes and external parasites and poultry. This product belong to the broad-spectrum resistant parasites.
Ivermectin for a variety of most of the life cycle of nematodes (but not all nematodes) role; For dish tail filarial microfilariae
effectively, but for adult worms; For only in intestinal fecal round worms are also effective.
Ivermectin has the selective inhibitory effect, with no spinal nerve cells and muscle cells in the animal glutamic acid chlorine ion channels of the valve is the high binding affinity, leading to the proliferation of the chloride ion permeability of cell membrane, cause nerve cells or muscle cells hyperpolarization, parasites paralysis or death.
Function
1. Ivermectin is the derivatives of abamectin. Ivermectin belongs to semisynthetic broad-spectrum resistant parasites.
2. Ivermectin has effect for most of the various life cycle nematodes.
3. Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.
4. Ivermectin has effect for dung round worms that is only stay in intestinal tract.
5. Ivermectin has selective inhibition.
6. Ivermectin can not go through the blood brain barrier of humanbeings.
Specification
Product Name | Ivermectin |
Quantity | 200.00kg |
Appearance | White or yellowish-white crystalline powder |
Solubility | Practically insoluble in water, freely soluble immethylene chloride,soluble in alcohol. |
Identification | A:Melting range 168-172ºC |
IR | Corresponds with that of CRS standard |
HPLC | The retention time for H2B1a and H2B1b corresponds with that of standard preparation |
Appearance of solution | Clear and not more intensely colored than BY1 |
Specific optical rotation(anhydrous and solvent-free substance) | -17 ~ -20 |
Related substances | Individual impurity(RRT1.3-1.5)≤2.5 |
Any other individual impurity≤1 | |
Total ≤5 | |
Disregard limit≤0.05 | |
Ethanol and Formamide(%) | Ethanol≤5.0 |
Formamide≤3.0 | |
Heavy metal(%) | ≤0.002 |
Water(%) | ≤1.0 |
Sulphated ash(%) | ≤0.1 |
Residue of solvent(toluene) | ≤890ppm |
Assay(%)(HPLC,on dry basis) | H2B1a(H2B1a+H2B1b)≥90.0 |
95.0≤H2B1a+H2B1b≤102.0 |