Basic Info.

Model NO.

HT190-2

Model NO.

HT190-2

Product Desciption

Compound acetyl salicylic acid tablet

Generic name Compound acetylsalicylic acid tablet

Main ingredients This product is a compound preparation with the components of: "each tablet contains aspirin 220mg, phenacetin 150mg and caffeine 35mg.

Indications: This product is used for fever, headache, neuralgia, toothache, menstrual pain, muscle pain and joint pain.

1. Common adverse reactions of acetyl salicylic acid compared with compound acetyl salicylic acid tablets:

(1) There are nausea, vomiting, upper abdominal discomfort or pain and other gastrointestinal reactions, which can disappear after withdrawal.

(2) Gastrointestinal bleeding or ulcer may occur when long-term or large amount of application.

(3) Reversible tinnitus and hearing loss may occur after taking a course of treatment.

(4) Allergic reactions such as asthma, urticaria, angioneurotic edema or shock may occur in a few patients, which may lead to death in severe cases.

(5) Excessive dose may cause liver and kidney function damage.

2. Phenacetin:

(1) Can cause renal papillary necrosis, interstitial nephritis and acute renal failure, and may even induce renal pelvis cancer and bladder cancer.

(2) Easy to use hemoglobin to form methemoglobin, so that the oxygen-carrying capacity of the blood decreased, causing cyanosis reaction.

(3) In addition, fenacetin can also cause hemolysis and hemolytic anemia, and has certain toxicity to the retina.

(4) Long-term use of phenacetin can also cause dependence on drugs.

(5) Fenacetin can also cause liver damage.

Contrainditions 1. People who are allergic to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs and caffeine should be contraindiated.

2. Hemophilia, active peptic ulcer and gastrointestinal bleeding caused by other reasons are prohibited.

3.3 Infants under the age of 3.3 months are prohibited.

1.6 Children under age and the elderly and infirm should use with caution.

2. Patients with asthma and other allergic reactions, glucose 6-phosphate dehydrogenase deficiency, gout patients, heart, liver and renal insufficiency, thrombocytopenia and other bleeding tendencies should be used with caution.

3. Hematocrit, liver function and serum salicylic acid content should be checked regularly during long-term large-scale application.

4. Cross-allergic reaction: Allergy to this product may also be allergic to another salicylic acid or another non-salicylic acid NONsteroidal anti-inflammatory drug. Be alert to the possibility of cross-allergic reaction.

5. Interference with diagnosis:

(1) When the daily dose of aspirin exceeded 2.4g for a long time, the copper sulfate urine glucose test and glucose enzyme urine glucose test could show false positive; Can interfere with urine ketone body test.

(2) When the plasma concentration was over 130μg/ mL, the high false value of uric acid could be obtained by colorimetric method, but it was not affected by uricase method.

(3) The determination of 5-hiAA in urine by fluorimetry may be interfered with by aspirin.

(4) The determination of urinary vanilla-based amygdalic acid (VMA) can be high or low due to different methods. Because aspirin inhibits platelet aggregation, it can make bleeding time longer.

(5) Liver function test, when the blood concentration of the drug is >250μg/ mL, alanine aminotransferase, aspartate aminotransferase and serum alkaline phosphatase can change abnormally, and the dosage can be restored to normal when the dosage is reduced. When the dosage is >300μg/ mL, the prothrombin time can be prolonged, and the serum cholesterol can be reduced when the daily dosage is over 5g.

(6) Due to the action of aspirin on the renal tubules, the increase in potassium excretion can lead to a decrease in blood potassium.

(7) The radioimmunoassay for the determination of serum thyroxine (T4) and triiodothyronine (T3) in high dose may yield low results.

(8) Reduced sulfophthalein excretion due to competitive excretion of aspirin with sulfophthalein in the renal tubules (i.e. PSP excretion test).

1. Aspirin in this product is easy to cross the placenta and should not be used by pregnant women because of possible effects on the fetus.

2. The lactating women can obtain a certain concentration of aspirin in their milk after taking this product, so the long-term application of large dose may cause the bleeding tendency and other adverse reactions of their infants.

1. Children patients, especially those with fever and dehydration, are prone to toxic reactions.

2. Reyesyndrome syndrome may occur in children with acute febrile diseases, especially influenza and chicken pox.

3.6 Children under the age of 3 months should be used with caution.

Medication for the elderly elderly patients due to the decline in renal function, taking this product is prone to toxic reactions, should be used with caution or appropriate dosage reduction.

Drug interactions were not tested and no reliable references were available.

Excessive use of this product should be avoided, which may cause damage to central nervous system, liver and kidney function, blood system, etc., should be treated once it occurs.

Drug toxicology 1. Aspirin and phenacetin have antipyretic analgesic action, can inhibit prostaglandin synthesis and release of the hypothalamus, to restore the normal reactivity of the temperature regulating center feeling neurons and antifebrile analgesia effect, also by inhibiting the synthesis of prostaglandins and other peripheral analgesia, anti-inflammatory and anti-rheumatism effect, and inhibition of platelet aggregation.

2. Coffee, as a central nerve stimulant, can stimulate the cerebral cortex, improve the sensitivity to the outside world, shrink the cerebrovascular, and strengthen the effect of the first two drugs to relieve headache.

3. Results of acute toxicity test: Oral LD50 of rats was 1500mg/kg; The mouse oral LD50 was 1100mg/kg.

Pharmacokinetics were not tested and no reliable references were available.


FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.


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