Product name: Cefaclor
Other names: Cefaclor; Cefaclor ampicillin
Chemical name: (6R, 7R) -7 - [(R) -2- amino-2-phenyl acetamido] -3-chloro-8-oxo-5-thia-1-azabicyclo [4.2.0 ] oct-2-ene-2-carboxylic acid monohydrate
English name: Cefaclor (Ceclor)
CAS: 53994-73-3
Formula: C15H14ClN3O4S.H2O
Molecular Weight: 385.82
Content: ≥98.5%
Properties: white powder, slightly smelly, bitter taste, soluble in water, soluble in methanol, chloroform, benzene
Usage: Cefaclor is a second-generation oral cephalosporin antibiotic drugs, a variety of gram-positive bacteria and gram-negative bacteria have a strong role in the killing, antibacterial effect is stronger than cefadroxil.

Cefaclor (cefaclor), chemical name (6R,7R)-7-[(R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5-thia-1-nitrogen Heterobicyclo[4.2.0]oct-2-ene-2-carboxylic acid, chemical formula is C15H14ClN3O4S, white to light yellow powder or crystalline powder, slightly odor, slightly soluble in water, in methanol, ethanol, trichloromethane or dichloromethane Almost insoluble in methyl chloride. Cefaclor is a β-lactam antibiotic and cephalosporin. It is a second-generation cephalosporin. It is mainly used for acute pharyngitis, acute tonsillitis, otitis media, bronchitis, pneumonia and other respiratory infections caused by sensitive bacteria. , Skin and soft tissue infections and urinary tract infections.

Product Description                                                                                     

A method for the synthesis of cefaclor using 7-amino-3-chlorinated cefacoalkanic acid and phenylglycine deng salt (ethyl sodium salt) as starting materials in a two-step process, characterized by the following steps:

1) mixed anhydride solution (mixed anhydride) was obtained by dissolving phenylglycine deng salt (ethyl sodium salt) and terpenyl chloride (trimethylacetyl chloride) in polar aprotic organic solvent under the action of pyridine catalyst.

2) 7-acca forms salt with nitrogenous organic base and dissolves in polar aprotic organic solvent to obtain 7-acca solution;

3) acylation condensation reaction was carried out between 7-acca solution and mixed anhydride under the condition of pyridine catalyst, and inorganic acid was added into the solution for hydrolysis, and the aqueous solution of cefaclor and acid salt was obtained by phase separation;

4) adding DMF or DMAC into the aqueous solution of cefaclor and acid salt to prepare cefaclor DMF or DMAC solvents under the condition of adding alkali;

5) cefaclor was obtained by conversion of DMF or DMAC solvents in aqueous and aqueous homogeneous organic solutions. The yield of cefaclor DMF complex reached 90%, and the total yield reached over 82%.



Application                                                                                 

Antibiotics. The antibacterial effect is stronger than cefalexin. It is mainly used for urinary tract infection, upper respiratory tract infection, skin and soft tissue infection and ent infection.