China Anti -GSK3 Alpha Rabbit Primary Polyclonal Antibody, Find details about China Primary Antibody, Primary Polyclonal Antibody from Anti -GSK3 Alpha Rabbit Primary Polyclonal Antibody
Description | GSK3 alpha rabbit polyclonal |
Protein full name | Glycogen synthase kinase-3 alpha |
Synonyms | GSK-3 alpha, Serine/threonine-protein kinase GSK3A, Gsk3a |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse GSK3 alpha |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cytoplasm, Nucleus |
Uniprot ID | Q2NL51, P18265 |
Applications
Applications | IHC | IF |
Species | Mouse, Rat | Mouse, Rat |
Dilution | 1: 1000-1: 2000 | 1: 500-1: 1000 |
Positive tissue | lung, heart, kidney, spinal cord, spleen, cerebellum | cerebellum, sepsis striatum, heart, spleen |
Background
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Images
Immunohistochemistry analysis of paraffin-embedded mouse lung using GSK3 alpha (GB111282) at dilution of 1: 2000 | |
Immunohistochemistry analysis of paraffin-embedded mouse heart using GSK3 alpha (GB111282) at dilution of 1: 2000 | |
Immunohistochemistry analysis of paraffin-embedded mouse kidney using GSK3 alpha (GB111282) at dilution of 1: 2000 | |
Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using GSK3 alpha (GB111282) at dilution of 1: 2000 | |
Immunohistochemistry analysis of paraffin-embedded mouse spleen using GSK3 alpha (GB111282) at dilution of 1: 2000 | |
Immunohistochemistry analysis of paraffin-embedded rat spleen using GSK3 alpha (GB111282) at dilution of 1: 2000 |
Storage
Storage | Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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1. Are you manufacturer?
Yes we are professional manufacturer for materials-antibodies and laboratory instruments & plastic-ware, and we can offer the best price for you.
2. Payment Terms:
We can accept 30% advance and before ship the goods to port pay the balance.
3. How about the quality?
We can offer the samples to you with free, you can check the quality before place the order.
4. How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
5. Could you offer a free sample for the quality test?
Free sample is available for customers, but freight cost shall be collected at your side.
Company information:
Wuhan Servicebio Technology Co., Ltd. was founded in 2007, headquartered in Wuhan Optical Valley Biological City, is a high-tech enterprise specializing in providing technical services and scientific research products for life and health science research. With more than 1000 employees and more than 40 service centers in large and medium-sized cities across the country, it can provide support and service to scientists who explore the mysteries of life in an all-round way.
The company has strong scientific research and service strength, has antibody research and development and production center, ultra-micro pathology center, pathological detection center, SPF experimental animal center and other technical platforms, (the company also) has a complete set of experimental platforms, instruments and equipment for pathological immune detection and analysis, and mastered the technical core and patented technology, and independently developed and optimized a variety of experimental methods and processes, and developed a number of matching reagents and consumables. The company has a special R & D team to produce and verify antibodies. Laboratory consumables centrifugal tubes and suckers have formed large-scale production and can be automated packaged. We can provide experimental design, method optimization, Experimental operation, analysis and testing, reagent consumables and other omni-directional integrated scientific research and technical services for customers.
The experimental instruments have passed the system certification, not only the internal introduction of ISO9001 quality management system, but also through the European Union CE security certification and FCC certification, National High-tech Enterprise Certification and so on.
The company has more than 500 kinds of products, exported to Europe, the Middle East, Southeast Asia, Africa, America and other countries. All the products are well received by customers. The lab instruments and consumables independently R&D by Servicebio are widely used in more than 200 cities in China.
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